Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Correction to: A Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma (Cells, (2022), 11, 9, (1439), 10.3390/cells11091439) [PDF]
The authors made the following changes to their paper [1]. The authors noticed a mistake on the SF-1 results for the cell line NCI-H295 in Figure 6. A mistake happened during data transfer for graph preparation.
Peitzsch M. +9 more
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
An aberrant axial element structure in spo11-1 mutants. [PDF]
Immunostaining of DSY2 (green) and DAPI staining (red) in WT (A, C, E, G) and spo11-1-Δ03 meiocytes (B, D, F, H). Maximal projection images are displayed for entire nuclei. Magnified images of 5 μm2 regions are shown in the middle panel.
Ding Hua Lee (8735694) +13 more
core +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Average degree K marginally influences the developmental profiles of graph parameters C and L. C and L development from connectivity matrices of alpha (6–13 Hz) oscillations are shown. [PDF]
A loess smooth is surrounded by 95% confidence intervals. Marked differences can be seen in the developmental plots, most prominent is the steady decrease in both C and L (relative to the random case) with increased K with a relatively intact curvature ...
Cornelis J. Stam (119688) +7 more
core +1 more source
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
On the Complexity of Consistency and Complete State Coding for Signal Transition Graphs [PDF]
Signal Transition Graphs (STGs) are a popular formalism for the specification of asynchronous circuits. A necessary condition for the implementability of an STG is the existence of a consistent and complete state encoding.
Javier Esparza
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Interspecies differences in H3K4me3, compared to H3K9ac, better predict expression divergence. [PDF]
(A) Correlation between interspecies expression differences and either H3K9ac (red) or H3K4me3 (blue) changes, at different regions along a gene, as indicated. Correlations were calculated for significant changes in expression and modifications (absolute
Yaron Mosesson (595197) +2 more
core +1 more source

