Results 201 to 210 of about 451,727 (304)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

<i>Aspergillus fumigatus</i>-induced acute fibrinous and organizing pneumonia complicated by spontaneous subcutaneous and mediastinal emphysema: a case report and literature review. [PDF]

Front Med (Lausanne)
Pi QZ, Wu M, Luo H.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Autologous stem cell transplantation versus consolidation chemotherapy as postremission treatment in newly diagnosed favorable- and intermediate-risk patients with AML: A comparative analysis of HOVON-SAKK-Nordic trials. [PDF]

Hemasphere
Kotsos D, Hazenberg C, Pabst T, Gradowska P, Manz MG, Maertens J, Graux C, Vekemans MC, Gjertsen BT, Lehmann S, Van Elssen CHMJ, Valk PJM, Vellenga E, Ossenkoppele G, Löwenberg B, Raaijmakers MHGP, Huls G, Versluis J.   +17 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The combination of alternating reduced-dose blinatumomab and hyper-CVAD as consolidation therapy in patients with newly-diagnosed adult B-cell acute lymphoblastic leukemia. [PDF]

Ther Adv Hematol
Li Z, Liu F, Zhang C, He J, Li W, Xie D, Jiang Y, Jin R, Gao T, Hong M, Wu Q.   +10 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Late-diagnosed pea aspiration in an adult mimicking a mass-like right lower-lobe lesion and requiring basal segmentectomy: A case report. [PDF]

Radiol Case Rep
Aldakak MA, Attaf H, Sahloul W, Ibrahim B, Dakka YA, Chaban H.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Education Research: Integrating AI-Enabled Interactive Case-Based Learning in a Preclinical Neurosciences Course. [PDF]

Neurol Educ
Kaplan TB, Wang K, Bichsel O, Bacchi S, Gheihman G.   +4 more
europepmc   +1 more source