Results 91 to 100 of about 2,853,808 (283)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Analytical solution of one-dimensional electroosmotic consolidation considering the thermal effect

Shuiwen dizhi gongcheng dizhi
In recent years, electro-osmotic method is an effective foundation treatment method for dredged silt; however, few studies have focused on the influence of temperature on the electro-osmotic consolidation. To explore the influence of temperature field on
Qi LU, Ganbin LIU, Yongzheng MA
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Differential Settlement of Intersecting Buildings in an Offshore Reclamation Project

Advances in Civil Engineering, 2019
This paper addresses the problem of open gaps caused by differential settlement in the process of constructing sluice buildings in soft soil beach areas, combined with the construction of sluice and supporting facilities in a reclamation project.
Jing-Bo Su, Zheng-yang Yu, Ya-Ru Lv, Yi-Huan Zhu, Hua-Qing Wang   +4 more
doaj   +1 more source

Studi Aplikasi Vacuum Preloading Sebagai Metode Alternatif Percepatan Proses Konsolidasi pada Tanah Lempung Lunak Jenuh Air: Trial GVS pada Perumahan Pantai Indah Kapuk, Jakarta

ComTech, 2011
Vacuum preloading is an alternative method to improve water-saturated soft clay by accelerating the consolidation process. A trial using GVS system was done at Pantai Indah Kapuk residence, Jakarta to investigate the system reliability.
Andryan Suhendra, Masyhur Irsyam
doaj   +1 more source

The Effect of variations in PVD installation distance and thickness of soft soil layer for the degree of consolidation and time of consolidation at Gunung Anyar, Surabaya

IOP Conference Series: Materials Science and Engineering, 2019
Gunung Anyar is one of the areas in East Surabaya which has quite a high indication of the spread of soil clay with The combined Cv is 0.0008 - 0.000125 cm 2/s, which indicates long a consolidation time. The appropriate soil improvement method to speed up the consolidation time is to use a combination of preloading and prefabricated vertical drain ...
M K Wardani, null Naufan
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Boosting Long-term Memory via Wakeful Rest: Intentional Rehearsal is not Necessary, Automatic Consolidation is Sufficient. [PDF]

, 2014
People perform better on tests of delayed free recall if learning is followed immediately by a short wakeful rest than by a short period of sensory stimulation.
Jessica Alber, Michaela Dewar (552107), Michaela Dewar, Sergio Della Sala (483451), Della Sala Sergio, Sergio Della Sala, Nelson Cowan (644841), Dewar Michaela, Jessica Alber (644840), Dewar, Michaela, Della Sala, Sergio, Alber, Jessica, Nelson Cowan, Dewar, Michaela T; id_orcid, Cowan, Nelson, Cowan Nelson, Alber Jessica   +16 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source