Results 61 to 70 of about 198,472 (283)

Neural Dynamics of Phonetic Trading Relations for Variable-Rate CV Syllables [PDF]

open access: yes, 1994
The perception of CV syllables exhibits a trading relationship between voice onset time (VOT) of a consonant and duration of a vowel. Percepts of [ba] and [wa] can, for example, depend on the durations of the consonant and vowel segments, with an ...
Boardman, Ian   +2 more
core   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

open access: yesFEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard   +7 more
wiley   +1 more source

Residues R177 and S178 of the human Na+/H+ antiporter NHA2 are involved in its inhibition by the flavonoid phloretin

open access: yesFEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.
The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova   +3 more
wiley   +1 more source

Consonant-Vowel-Consonants for Error-Free Code Entry

open access: yes, 2019
Codes and passwords are the bane of user experiences: even small mistakes can delay desired activities, causing undue frustration. Work on codes has focused on security instead of people’s ability to enter them error-free. Difficulties observed in a security demonstration motivated this investigation of code transcription difficulty. A pilot study with
Blanchard, Nikola, K   +2 more
openaire   +5 more sources

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

open access: yesFEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti   +2 more
wiley   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

open access: yesFEBS Letters, Volume 599, Issue 9, Page 1260-1268, May 2025.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr   +4 more
wiley   +1 more source

Consonant Cascades [PDF]

open access: yes, 2002
Concluding a series on meaningful word ladders, here\u27s another special type of ladder. Consonant cascades (CCs) are meaningful cases of consonant movements (CMs) in which all substitutions occur at the same position.

core   +1 more source

Measuring consonant identification in nonsense syllables, words, and sentences.

open access: yesJournal of rehabilitation research and development, 2010
Sensorineural hearing loss (SNHL) produces deficits in speech comprehension in noise that primarily are due to impairments in identifying consonants.
D. Woods, E. Yund, T. Herron
semanticscholar   +1 more source

The Meanings of Consonants

open access: yesAnnual Meeting of the Berkeley Linguistics Society, 2003
Proceedings of the Twenty-Ninth Annual Meeting of the Berkeley Linguistics Society: General Session and Parasession on Phonetic Sources of Phonological Patterns: Synchronic and Diachronic Explanations (2003)
William R. Leben   +2 more
openaire   +2 more sources

Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα

open access: yesFEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.
We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl   +2 more
wiley   +1 more source

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