Results 91 to 100 of about 1,139,564 (257)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Analyzing Arabic-English interlanguage coda consonant clusters : optimality theoretic approach / Ala'a Mohammed Amin A Turkustani [PDF]
, 2011 The study investigates the problematic English coda consonant clusters which Arabic speakers have in pronouncing English. This investigation involves a constraint-based analysis of interlanguage syllable structure within the optimality framework to see ...
Turkustani, Ala'a Mohammed Amin A
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The Roles of Segments and Tone in Mandarin Lexical Processing: An ERP Study
Journal of Integrative NeuroscienceBackgrounds: Segments and tone are important sub-syllabic units that play large roles in lexical processing in tonal languages. However, their roles in lexical processing remain unclear, and the event-related potential (ERP) technique will benefit the ...
Dan Du, Minghu Jiang
doaj +1 more source
Personal Responsibility for Health
Voices in Bioethics, 2015 The phone rings. It is 2:30 a.m. Saturday morning. The call is from the hospital. A 59-year-old was brought to the ER with acute onset of severe headache soon followed by collapse.
Zelig Weinstein
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
, 2010 Elsewhere I have argued that the Indo-European verbal system can be understood in terms of its Indo-Uralic origins because the reconstructed Indo-European endings can be derived from combinations of Indo-Uralic morphemes by a series of well-motivated ...
Kortlandt, Frederik H. H.
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Learning and unlearning voicing assimilation
Frontiers in Language SciencesThis study investigates how postlexical phonological processes are acquired in multilingual speech, namely, how learners cope with conflicting demands in the production and perception of the voicing patterns in their non-native languages, what impact ...
Zsuzsanna Bárkányi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source