Results 131 to 140 of about 25,115 (305)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Investigating Emphatic Consonants in Foreign Accented Arabic
, 2009 This paper investigates the four emphatic consonants of Arabic from the point of view of automatic speech recognition. Comparisons of the recognition error rates for these phonemes and for their non-emphatic counterparts are analyzed in five ...
Yousef Ajami Alotaibi +5 more
core +1 more source
LanguagesA sociophonetic study of coda /t/ in Australian Englishes spoken in Warrnambool and Mildura, Victoria, Australia, is described. A total of 2112 coda /t/ tokens produced by 61 adult L1 speakers was analyzed using auditory and acoustic profiling, focusing ...
Debbie Loakes +2 more
doaj +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
“Say Again?” An In-house, Online, Self-access Pronunciation Project for ESOL Students
Studies in Self-Access Learning Journal, 2014 This collaborative project comprises the creation of free online pronunciation activities which are geared specifically for independent learning, although classroom use is also valuable.
Menaka Ediriweera +2 more
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 1990 Weekly series appearing in a national newspaper. Graham Rawle's 'Lost Consonants' is a text and image word play series that illustrates a sentence from which one vital letter has been removed, altering its meaning.
Rawle, Graham; id_orcid
core