Results 91 to 100 of about 188,688 (357)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Cryptoendolith colonization of diverse substrates (1): cultivation and characterization [PDF]

, 2005
We are investigating whether cryptoendolithic microorganisms are able to colonize diverse substrates through biogenic weathering. This first part of the study involves the cultivation and characterization of microbial consortia from Antarctic sandstone ...
Blackhurst, R. L., Genge, M. J., Grady, M. M., Jadbubansa, P., Roberts, D.   +4 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

In situ intein-mediated multiprotein assembly via engineered cross-species consortia

Frontiers in Bioengineering and Biotechnology
Inteins can connect flanking external proteins into a new protein fragment and excise themselves. Here, we report the in situ splicing of proteins by engineered microbial consortia. This study pioneers a programmable microbial consortia platform enabling
Hao Wang, Jiajia Kang, Hui Gao
doaj   +1 more source

Deep-Sea Archaea Fix and Share Nitrogen in Methane-Consuming Microbial Consortia [PDF]

, 2009
Nitrogen-fixing (diazotrophic) microorganisms regulate productivity in diverse ecosystems; however, the identities of diazotrophs are unknown in many oceanic environments. Using single-cell–resolution nanometer secondary ion mass spectrometry images of ^(
Dekas, Anne E., Orphan, Victoria J., Poretsky, Rachel S.   +2 more
core   +2 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Synergistic Effect of Serratia fonticola and Pseudomonas koreensis on Mitigating Salt Stress in Cucumis sativus L.

Current Issues in Molecular Biology
Beneficial microbes enhance plant growth and development, even under stressful conditions. Serratia fonticola (S1T1) and Pseudomonas koreensis (S4T10) are two multi-trait plant growth-promoting rhizobacteria (PGPRs) that are resistant to saline ...
Sajid Ali, Murtaza Khan, Yong-Sun Moon
doaj   +1 more source

Advanced Manufacturing: New Emphasis in Industrial Development

Foresight and STI Governance, 2014
The article presents the economic concepts of advanced manufacturing and suggests promising interconnected technologies that could lead to new industrial infrastructures. The authors estimate Russia’s standing in popular areas of advanced manufacturing (
Irina Dezhina, Alexey Ponomarev
doaj   +1 more source

Metatranscriptomic Sequencing of a Cyanobacterial Soil-Surface Consortium with and without a Diverse Underlying Soil Microbiome. [PDF]

, 2020
Soil surface consortia are easily observed and sampled, allowing examination of their interactions with soil microbiomes. Here, we present metatranscriptomic sequences from Dark Green 1 (DG1), a cyanobacterium-based soil surface consortium, in the ...
Bell, Terrence H, Bruns, Mary Ann, Clum, Alicia, Copeland, Alex, Daum, Chris, Eloe-Fadrosh, Emiley A, Foster, Brian, Foster, Bryce, Huntemann, Marcel, Ivanova, Natalia N, Kyrpides, Nikos C, Mukherjee, Supratim, Palaniappan, Krishnaveni, Peng, Xin, Pennacchio, Christa, Reddy, TBK, Roux, Simon, Trexler, Ryan V, Varghese, Neha   +18 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source