Results 31 to 40 of about 902,258 (265)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Granular behaviour under bi-directional shear with constant vertical stress and constant volume

Journal of Rock Mechanics and Geotechnical Engineering
This paper aims to investigate the role of bi-directional shear in the mechanical behaviour of granular materials and macro-micro relations by conducting experiments and discrete element method (DEM) modelling.
Min Zhang, Yunming Yang, Hanwen Zhang, Qi Li   +3 more
doaj   +1 more source

Volume change behavior of bentonite-sand mixture under constant suction condition

MATEC Web of Conferences, 2018
The unsaturated state of soil can raise many geotechnical problems upon wetting-drying cycles such as volume change resulting in collapse or swell, change in the shear strength, and change in the hydraulic conductivity.
Al-Badran Yasir, Schanz Tom
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mixed Convection of Variable Properties Al2O3-EG-Water Nanofluid in a Two-Dimensional Lid-Driven Enclosure [PDF]

Transport Phenomena in Nano and Micro Scales, 2013
In this paper, mixed convection of Al2O3-EG-Water nanofluid in a square lid-driven enclosure is investigated numerically. The focus of this study is on the effects of variable thermophysical properties of the nanofluid on the heat transfer ...
G.A. Sheikhzadeh, H. Khorasanizadeh, S.P. Ghaffari   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Effects of temperature and volume of water on the growth and development of tadpoles of Pleurodema diplolister and Rhinella granulosa (Amphibia: Anura)

Zoologia (Curitiba), 2009
The capacity of tadpoles to reduce their metamorphosis time and body size in response to fluctuations in environmental variables of temporary ponds has been recorded in field and laboratory studies. The main alterations in this habitat are related to the
Thely A. Maciel, Flora A. Juncá
doaj   +1 more source

A fundamental study of prechamber combustion characteristics in a constant volume combustion chamber

Nihon Kikai Gakkai ronbunshu, 2020
The prechamber combustion characteristics were studied using a constant volume combustion chamber to improve the efficiency of cogeneration natural gas engines.
Seiya UENO, Yosuke SATAKE, Taiga TAKAYAMA, Fumio SHIMADA, Kimitoshi TANOUE, Yasuo MORIYOSHI   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source