Results 41 to 50 of about 902,258 (265)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Creep Behavior in Fiber-Reinforced Epoxy (DGEBA) Composites [PDF]
Engineering and Technology Journal, 2013 The composite material was prepared by reinforcing the epoxy with E-glass fiber. The creep and flextural test were measured in this work for one and two layer of E-glass fiber with volume fraction rate of (10%, 20%, 30%, and 40%) in orientation of (0-90o)
Lubna Ghalib
doaj +1 more source
Small Volume Bodies of Constant Width
International Mathematics Research NoticesAbstract For every large enough $n$, we explicitly construct a body of constant width $2$ that has volume less than $0.9^{n} \textrm{Vol}(\mathbb{B}^{n}$), where ${{\mathbb{B}}}^{n}$ is the unit ball in $\mathbb{R}^{n}$. This answers a question of O. Schramm.
Arman, Andrii +4 more
openaire +3 more sources
Carbonization of Biomass in Constant-Volume Reactors
Energy & Fuels, 2017 A novel carbonization process that realizes near-theoretical fixed-carbon yields in ~3 h is presented. Norwegian spruce and birch sawdusts were carbonized in a hermetically-sealed reactor at an initial nitrogen pressure of 0.1 MPa. During a carbonization test, the reactor vessel retained all pyrolytic products inside the hot reaction zone invoking high
Maider Legarra +5 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Toolpath Generation on 3-Axes Milling Using Constant Volume Method
Journal of Mechanical EngineeringA new simple method to generate toolpaths when machining based on the fixed base of the residual metal portion left after each longitudinal (forward step) and transverse cutting step (stepover) is presented in this paper.
Van-Quy Hoang
doaj +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
MATEC Web of Conferences, 2016 The stricter on emission legislation and growing demands for lower fuel consumption require significant efforts to improve combustion efficiency while satisfying the demand of emission quality.
Baddu Nuriati +4 more
doaj +1 more source