Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas
Annals of Neurology, EarlyView.Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek +7 more
wiley +1 more source
Lifestyle and Chronic Constipation in Medical Students
Gastroenterology Research and Practice, 2021 Aim. Constipation is one of the most common complaints of the digestive system indicated with an increase in defecation frequency, difficulty in defecation, and hard and strained defecation.
Mehmet Aykut Yildirim +9 more
doaj +1 more source
Medical Journal of Australia, 2018 Chronic idiopathic constipation (CIC) is one of the most common gastrointestinal disorders, with a global prevalence of 14%. It is commoner in women and its prevalence increases with age.
C. Black, A. Ford
semanticscholar +1 more source
Turning Slowly Predicts Future Diagnosis of Parkinson's Disease: A Decade‐Long Longitudinal Analysis
Annals of Neurology, EarlyView.Objective Wearable technology allows accurate measurement of turning while walking, with cross‐sectional studies indicating that difficulty turning presents even in preclinical phases of Parkinson's disease. The aim of our study was to quantify rate of change of turning performance in a cohort of older adults, and test whether turning decline can ...
Morad Elshehabi +9 more
wiley +1 more source
The development of a new measure of quality of life in the management of gastro-oesophageal reflux disease: the Reflux Questionnaire. [PDF]
, 2007 INTRODUCTION This paper reports on the development of a new measure of health-related quality of life for use among patients with gastro-oesophageal reflux disease (GORD), funded as part of the REFLUX trial.
C Jenkinson +22 more
core +1 more source
Gastroenterology, 2016 BACKGROUND & AIMS In fecal samples from patients with chronic constipation, the microbiota differs from that of healthy subjects. However, the profiles of fecal microbiota only partially replicate those of the mucosal microbiota.
G. Parthasarathy +7 more
semanticscholar +1 more source
Expert Perspective: Diagnosis and Treatment of Castleman Disease
Arthritis &Rheumatology, EarlyView.Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y. C. Chen +2 more
wiley +1 more source
Are Concepts About Constipation and Dietary Fiber Changing?
Hospital Practices and Research, 2017 After reading in detail the valuable review article by Korgh et al1 regarding chronic constipation management, we would like to mention some new points about chronic constipation which were not considered in this review.
Shahram Manoochehry, Hamid Reza Rasouli
doaj +1 more source
Comparison of three with six regions of interest analyses in patients with idiopathic constipation undertaking colon transit scintigraphy using 67Ga-citrate [PDF]
, 2013 OBJECTIVE AND INTRODUCTION: Preparation of data from 6 geometric regions of interest in the colon is time consuming, and can become impractical in the environment of busy Nuclear Medicine Departments.
Asli, I.N. +5 more
core
Multimorbidity in bipolar disorder and under-treatment of cardiovascular disease: a cross sectional study [PDF]
, 2013 Background: Individuals with serious mental disorders experience poor physical health, especially increased rates of cardiometabolic morbidity and premature morbidity.
A Weeke +42 more
core +2 more sources