FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
DIGITAL TWIN: A HBIM-BASED METHODOLOGY TO SUPPORT PREVENTIVE CONSERVATION OF HISTORIC ASSETS THROUGH HERITAGE SIGNIFICANCE AWARENESS [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019 During preliminary phases of conservation projects, a considerable amount of heterogeneous datasets are produced, gathered, analysed and interpreted.
P. Jouan, P. Hallot
doaj +1 more source
The Lisbon Treaty: a constitutional document, not a constitution–a British perspective [PDF]
, 2010 The European Union has undergone a constitutional transformation in the past half century. It has evolved from its origins as the European Economic Community, promoting economic integration, into a supranational polity that has come to be perceived in
Bremner, Phillip
core
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Constitutional Remedies as Constitutional Law
SSRN Electronic Journal, 2020 Virtually all constitutional scholars agree, and the Supreme Court has uniformly held, that our entire system of constitutional democracy is premised in important part on the dictate of judicial review, i.e., the power of the judiciary to exercise the final say as to the meaning of the provisions of the counter-majoritarian Constitution.
openaire +3 more sources
The Constitutional Treaty as a Reflexive Constitution [PDF]
German Law Journal, 2005 The “Treaty establishing a Constitution for Europe” elicits divergent scholarly responses. An apologetic view holds that it is the best of all possible constitutions, given the current constellations of political forces. Such a viewpoint is countered by a mixed choir of critics for whom the document is simply another treaty, a “nostalgic project,” or a
openaire +1 more source
Tragic Irony of American Federalism: National Sovereignty versus State Sovereignty in Slavery and in Freedom, The Federalism in the 21st Century: Historical Perspectives [PDF]
, 1996 A plurality on the Supreme Court seeks to establish a state-sovereignty based theory of federalism that imposes sharp limitations on Congress\u27s legislative powers.
Kaczorowski, Robert J.
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
How does Pancasila work to solve social problems?
Indonesian Journal of Pancasila and Global Constitutionalism, 2023 This study discusses the relationship that Pancasila has with the way it is used to overcome social problems that exist in Indonesia. This study uses the literature review method which explains that researchers in working only use sources from other ...
Ahmad Yanta Fairuz Zudana
doaj +1 more source
THE GREEN CONSTITUTION CONCEPT IN THE 1945 CONSTITUTION OF THE REPUBLIC OF INDONESIA
, 2018 This article aims to analyze the concept of Green Constitution in The Amandment of Constitution of Indonesia . The method used is a normative juridical, with secondary data which analyzed in qualitative .
Sekar Anggun Gading Pinilih
semanticscholar +1 more source