Results 111 to 120 of about 46,692 (260)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The development of advanced creep constitutive equations for high chromium alloy steel (P91) at transition stress range [PDF]

Creep damage is a time-dependent deformation in metals under a constant stress at high temperature condition. Since the 1980s, high chromium alloy steel P91 (9%Cr-1%Mo-0.25%V) is highly demanded in high temperature industries (Saha, 2003).
An, Lili
core  

A Constitutive Equation for Cyclically Loaded Sands [PDF]

, 1981
A rate type constitutive equation with internal parameters is proposed for describing the behaviour of cyclically loaded sands in undrained conditions leading to liquefaction. The mathematical model is checked versus experimental data on undrained cyclic
Szavits-Nossan, A., Kvasnicka, P.
core   +1 more source

JOURNAL OF THERMAL STRESSES [PDF]

, 2015
A new constitutive equation of thermoelasticity for crystals is presented based on the interatomic potential and solid mechanics at finite temperature. Using the new constitutive equation, the calculations for crystal copper and graphene are carried out ...
Liu XL, Wang, TC (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, 15 Beisihuanxi Rd, Beijing 100190, Peoples R China., Tang QH(汤奇恒), Wang ZQ(王自强), Chen C(陈岑)   +4 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Development and Validation of the Creep Damage Constitutive Equations for P91 Alloy [PDF]

This paper presents research on the validation of a set of creep damage constitutive equations for P91 alloy under multi-axial states of stress, and its applicability under lower stress level.
Yang, Xin, Xu, Qiang, Lu, Zhongyu
core  

Empirical Natural Closure Relation for Short Fiber Suspension Models [PDF]

, 2007
L'auteur Francisco CHINESTA faisait parti en 2007 du Laboratoire de Mécanique des Systèmes et des Procédés (LMSP). Depuis 2010, le LMSP a fusionné avec deux autres unités de recherche en un seul laboratoire intitulé PIMM (Procédés et Ingénierie en ...
CHINESTA SORIA, Francisco, Chinesta, Francisco, PRULIERE, Etienne, AMMAR, Amine   +3 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Determining Johnson-Cook Constitutive Equation for Low-Carbon Steel via Taylor Anvil Test. [PDF]

Materials (Basel), 2021
Kunčická L, Jopek M, Kocich R, Dvořák K.   +3 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source