RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin [PDF]
eLife, 2017 Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear.
Whitney L Johnson +7 more
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Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements [PDF]
Cells, 2022 Transposable elements (TEs) are abundant components of constitutive heterochromatin of the most diverse evolutionarily distant organisms. TEs enrichment in constitutive heterochromatin was originally described in the model organism Drosophila ...
René Massimiliano Marsano +1 more
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The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control [PDF]
Cells, 2022 Constitutive heterochromatin represents a significant fraction of eukaryotic genomes (10% in Arabidopsis, 20% in humans, 30% in D. melanogaster, and up to 85% in certain nematodes) and shares similar genetic and molecular properties in animal and plant ...
Giovanni Messina +4 more
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Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction [PDF]
NucleusAberrant nuclear morphology is a hallmark of human disease and causes nuclear dysfunction. Perturbed nuclear mechanics via reduced heterochromatin weakens the nucleus resulting in nuclear blebbing and rupture.
Gianna Manning +4 more
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Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus [PDF]
Viruses, 2021 The success of long-term host–virus partnerships is predicated on the ability of the host to limit the destructive potential of the virus and the virus’s skill in manipulating its host to persist undetected yet replicate efficiently when needed.
Sumita Bhaduri-McIntosh +1 more
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Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair [PDF]
Nucleus, 2019 Constitutive heterochromatin is considered as a functionally inert genome compartment, important for its architecture and stability. How such stable structure is maintained is not well understood.
Vadim O. Chagin +7 more
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Dynamic association of H3K36me3 with pericentromeric heterochromatin regulates its replication time [PDF]
EMBO ReportsThe flexibility of the spatio-temporal genome replication program during development and disease highlights the regulatory role of plastic epigenetic mechanisms over genetic determinants. Histone post-translational modifications are broadly implicated in
Sunil Kumar Pradhan +5 more
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Ring-like distribution of constitutive heterochromatin in bovine senescent cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochromatin ...
Andrey Pichugin +3 more
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The nuclear poly(A)-binding protein Pab2/PABPN1 promotes heterochromatin assembly through the formation of Pab2 nuclear condensates. [PDF]
PLoS GeneticsThe assembly of constitutive heterochromatin is a prerequisite for maintaining genome stability. However, the mechanism of heterochromatin formation has yet to be completely understood.
Ziyue Liu +3 more
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Sequence-dependent heterochromatin formation in the human malaria parasite Plasmodium falciparum
Heliyon, 2023 The human malaria parasite Plasmodium falciparum represses transcription of the gene encoding AP2-G, which is the master regulator of germ cell differentiation, via heterochromatin condensation following histone H3 lysine 9 trimethylation (H3K9me3 ...
Toshiyuki Mori, Mai Nakashima
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