Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements. [PDF]
Cells, 2022 Transposable elements (TEs) are abundant components of constitutive heterochromatin of the most diverse evolutionarily distant organisms. TEs enrichment in constitutive heterochromatin was originally described in the model organism Drosophila ...
Marsano RM, Dimitri P.
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Ring-like distribution of constitutive heterochromatin in bovine senescent cells. [PDF]
PLoS One, 2011 BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochromatin ...
Pichugin A +3 more
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Inflammasome, the Constitutive Heterochromatin Machinery, and Replication of an Oncogenic Herpesvirus. [PDF]
Viruses, 2021 The success of long-term host–virus partnerships is predicated on the ability of the host to limit the destructive potential of the virus and the virus’s skill in manipulating its host to persist undetected yet replicate efficiently when needed.
Bhaduri-McIntosh S, McIntosh MT.
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RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin. [PDF]
Elife, 2017 Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear.
Johnson WL +7 more
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Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair. [PDF]
Nucleus, 2019 Constitutive heterochromatin is considered as a functionally inert genome compartment, important for its architecture and stability. How such stable structure is maintained is not well understood.
Chagin VO +7 more
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Peripheral re-localization of constitutive heterochromatin advances its replication timing and impairs maintenance of silencing marks. [PDF]
Nucleic Acids Res, 2018 The replication of the genome is a highly organized process, both spatially and temporally. Although a lot is known on the composition of the basic replication machinery, how its activity is regulated is mostly unknown.
Heinz KS +6 more
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Loss of HP1 causes depletion of H3K27me3 from facultative heterochromatin and gain of H3K27me2 at constitutive heterochromatin. [PDF]
Genome Res, 2016 Methylated lysine 27 on histone H3 (H3K27me) marks repressed “facultative heterochromatin,” including developmentally regulated genes in plants and animals.
Jamieson K +7 more
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Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction [PDF]
NucleusAberrant nuclear morphology is a hallmark of human disease and causes nuclear dysfunction. Perturbed nuclear mechanics via reduced heterochromatin weakens the nucleus resulting in nuclear blebbing and rupture.
Manning G +4 more
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Molecular characterization of constitutive heterochromatin in three species of Trypoxylon (Hymenoptera, Crabronidae, Trypoxylini) by CMA3/DAPI staining [PDF]
Comparative Cytogenetics, 2011 Previous cytogenetic analyses in Trypoxylon Latreille, 1796 have been basically restricted to C-banding. In the present study, base-specific CMA3 and DAPI fluorochrome staining were used to characterize the constitutive heterochromatin in three ...
Rodolpho Menezes +3 more
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HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin. [PDF]
Nucleic Acids Res, 2023 Nucleoli are nuclear compartments regulating ribosome biogenesis and cell growth. In embryonic stem cells (ESCs), nucleoli containing transcriptionally active ribosomal genes are spatially separated from pericentromeric satellite repeat sequences ...
Ballmer D +7 more
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