Results 91 to 100 of about 353,053 (207)

High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model

Epigenetics & Chromatin, 2009
Background Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that show variegation of the eye color ...
Vogel Maartje J, Pagie Ludo, Talhout Wendy, Nieuwland Marja, Kerkhoven Ron M, van Steensel Bas   +5 more
doaj   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Satellite DNA sites in four species of the genus Astyanax (Teleostei, Characiformes)

Genetics and Molecular Biology, 2007
Cytogenetic data about satellite DNA distribution in four Astyanax species (Characidae) from the Paraitinga river, Paraíba do Sul river basin, Brazil, are presented. In order to characterize the constitutive heterochromatin, C-banding, chromomycin A3 and
Karine Frehner Kavalco, Rubens Pazza, Luiz Antonio Carlos Bertollo, Orlando Moreira-Filho   +3 more
doaj   +1 more source

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

Medicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis, Marta Ribalta‐Vilella, Alba Irisarri, Pinky Gehlot, Bhanwar Singh Choudhary, Abhisek Jana, Vivek Kumar Vyas, Deb Ranjan Banerjee, Mercè Pallàs, Ana Guerrero, Christian Griñán‐Ferré   +10 more
wiley   +1 more source

A Solution Set-Based Entropy Principle for Constitutive Modeling in Mechanics [PDF]

, 2018
Entropy principles based on thermodynamic consistency requirements are widely used for constitutive modeling in continuum mechanics, providing physical constraints on a priori unknown constitutive functions. The well-known M\"uller-Liu procedure is based on Liu's lemma for linear systems.
arxiv   +1 more source

The significance of PAX5 in Merkel cell carcinoma

The Journal of Pathology, Volume 266, Issue 1, Page 81-94, May 2025.
Abstract Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial‐, neuroendocrine‐, and lymphoid‐associated genes. Here, we focused on B‐cell differentiation, which is characterised by the coexpression of PAX5 and TdT. PAX5 is the master regulator of B‐cell commitment and is expressed in 65% of MCC cases.
Emil Chteinberg, Julia Kolarova, Julia Vogt, Amanda Macamo, Felix Bormann, Helene Kretzmer, Ernst Jan Speel, Joost van den Oord, Christof Schneider, Stephan Stilgenbauer, Jürgen C Becker, Véronique Winnepenninckx, Erik Biessen, Martin Zenke, Anna Kordelia Kurz, Reiner Siebert, Axel zur Hausen   +16 more
wiley   +1 more source

The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation [PDF]

arXiv, 2013
Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are hypertranscribed due to dosage compensation. Here, we dissect the molecular mechanisms and functional pressures driving heterochromatin formation and dosage compensation of the recently formed neo-sex chromosomes ...
arxiv  

Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease

Brain Pathology, Volume 35, Issue 3, May 2025.
Aerobic exercise improves transfer of healthy mitochondria from astrocytes to neurons in the 5 × FAD mice. Abstract Mitochondrial dysfunction is a well‐established hallmark of Alzheimer's disease (AD). Despite recent documentation of transcellular mitochondrial transfer, its role in the pathogenesis of AD remains unclear.
Jiachen Cai, Yan Chen, Yuzhu She, Xiaoxin He, Hu Feng, Huaiqing Sun, Mengmei Yin, Junying Gao, Chengyu Sheng, Qian Li, Ming Xiao   +10 more
wiley   +1 more source

Changes in chromatin state in donors subjected to physical stress [PDF]

arXiv, 2009
The purpose of the present study is to evaluate changes in chromatin of human buccal epithelium under the influence of stressing factor - dosed physical activity. Investigations were performed in a group of students (13 men) of age 19-23. Cells were stained on a slide by a 2% orcein solution in 45% acetic acid during 1 h.
arxiv  

Dynamics of constitutive heterochromatin: two contrasted kinetics of genome restructuring in early cloned bovine embryos.

Reproduction, 2010
Efficient reprograming of the donor cell genome in nuclear transfer (NT) embryos is linked to the ability of the embryos to sustain full-term development.
A. Pichugin, D. Le Bourhis, P. Adenot, Gaëtan Lehmann, C. Audouard, J. Renard, X. Vignon, N. Beaujean   +7 more
semanticscholar   +1 more source