Results 91 to 100 of about 346,273 (274)

DNA and heterochromatin cycles in male gamete development of Oedogonium

Acta Societatis Botanicorum Poloniae, 2014
In antheridial nuclei of Oedogonium cardiacum (Hass.) Wittr. during male gamete formation, the DNA presynthetic period is shortened, the synthetic and postsynthetic periods are lengthened (G1 - 15%, S - 58%, G2 - 29%) as compared with those in vegetative
S. P. Shpilevaya
doaj   +1 more source

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84 [PDF]

, 1986
The localization of chromosome 18 in human interphase nuclei is demonstrated by use of radioactive and nonradioactive in situ hybridization techniques with a DNA clone designated L1.84.
A. Brückner, AHN Hopman, AL Jørgensen, AR Mitchell, B Trask, BU Zabel, CD Bloomfield, D Pinkel, GA Rappold, GA Rappold, H Hoehn, H. D. Hager, H. P. Scholl, HF Willard, J Wolfe, J. Landegent, JC Wu, JE Landegent, JE Landegent, L Manuelidis, LA Herzenberg, M Schardin, M Schmid, M Spaeter, M. Schardin, M. van der Ploeg, MM LeBeau, P Devilee, P Devilee, P. Devilee, P. Pearson, T Cremer, T. Cremer, W Schempp   +33 more
core   +1 more source

Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging

Aging Cell, 2022
Mammalian oocyte quality reduces with age. We show that prior to the occurrence of significant aneuploidy (9M in mouse), heterochromatin histone marks are lost, and oocyte maturation is impaired.
Peera Wasserzug-Pash, Rachel Rothman, E. Reich, Lital Zecharyahu, O. Schonberger, Yifat Weiss, N. Srebnik, Yaara Cohen-Hadad, A. Weintraub, I. Ben‐Ami, H. Holzer, Michael Klutstein   +11 more
semanticscholar   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Targets of histone H3 lysine 9 methyltransferases

Frontiers in Cell and Developmental Biology, 2022
Histone H3 lysine 9 di- and trimethylation are well-established marks of constitutively silenced heterochromatin domains found at repetitive DNA elements including pericentromeres, telomeres, and transposons. Loss of heterochromatin at these sites causes
Aidan J. Levinsky, Aidan J. Levinsky, Gregor McEdwards, Gregor McEdwards, Nasha Sethna, Nasha Sethna, Mark A. Currie, Mark A. Currie   +7 more
doaj   +1 more source

Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3-H4 histones and lamin-B receptor [PDF]

, 2015
Diverting a protein from its intracellular location is a unique property of intrabodies. To interfere with the intracellular traffic of heterochromatin protein 1β (HP1β) in living cells, we have generated a cytoplasmic targeted anti-HP1β intrabody ...
Ainsztein, Akhtar, Alessio Cardinale, Aucott, Bannister, Billur, Biocca, Brown, Bult, Butler, Canzio, Cardinale, Cardinale, Cardinale, Cheutin, Chiti, Cohen, Cowell, Dialynas, Filesi, Filesi, Griffin, Hawkins, Horsley, Ilaria Filesi, Jannot, Jenuwein, Jones, Kirilyuk, Kourmouli, Krebber, Kvam, Lachner, Lavigne, Lechner, Lee, Lener, Lo, Luijsterburg, Mateos-Langerak, Meehan, Minc, Monneret, Muchardt, Nakayama, Nishibuchi, Olins, Olzscha, Orlandi, Ostermeier, Peric-Hupkes, Persic, Poleshko, Polioudaki, Prim B. Singh, Rajpal, Sblattero, Silva, Silvia Biocca, Singh, Smothers, Soria, Taddei, Uversky, Wang, Wreggett, Ye, Ye, Zhang, Zhu   +69 more
core   +1 more source

Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens

PROTEOMICS, EarlyView.
ABSTRACT Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs’ resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM patients’ response to commonly used therapeutic regimens.
Foteini Paradeisi, Aggeliki Tserga, Vasiliki Lygirou, Manousos Makridakis, Rafael Stroggilos, Grigoris Georgiou, George M. Spyrou, Ioannis V. Kostopoulos, Christine‐Ivy Liacos, Aikaterini Termentzi, Meletios A. Dimopoulos, Ourania Tsitsilonis, Antonia Vlahou, Efstathios Kastritis, Jerome Zoidakis   +14 more
wiley   +1 more source

Chromosome study in Schistocerca (Orthoptera-Acrididae-Cyrtacanthacridinae): karyotypes and distribution patterns of constitutive heterochromatin and nucleolus organizer regions (NORs)

Genetics and Molecular Biology, 2007
Chromosome analyses were performed in two grasshopper species of the genus Schistocerca, S. pallens and S. flavofasciata. Both species shared the same diploid number (2n = 23, X in males; 2n = 24, XX in females);and a conserved karyotype composed ...
Maria José de Souza, Natoniel Franklin de Melo   +1 more
doaj   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Nuclear destabilisation – a possible genesis of cancer?

Biological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal   +4 more
wiley   +1 more source