Results 111 to 120 of about 346,273 (274)

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons [PDF]

, 2014
Alternative splicing—the production of multiple messenger RNA isoforms from a single gene—is regulated in part by RNA binding proteins. While the RBPs transformer2 alpha (Tra2α) and Tra2β have both been implicated in the regulation of alternative ...
Austin, Caroline A., Best, Andrew, Chabot, Benoit, Cheong Lee, Ka, Cowell, Ian G., Curk, Tomaz, Dalgliesh, Caroline, Danilenko, Marina, Elliott, David J., Hong, Elaine, Hussain, Rafiq, James, Katherine, Keavney, Bernard, Kheirolahi-Kouhestani, Mahsa, Klinck, Roscoe, Santibanez Koref, Mauro, Tyson-Capper, Alison, Venables, Julian P., Wipat, Anil, Xu, Yaobo   +19 more
core   +2 more sources

A new piece in the repeatome puzzle of Triatominae bugs: The analysis of Triatoma rubrofasciata reveals the role of satellite DNAs in the karyotypic evolution of distinct lineages

Insect Molecular Biology, EarlyView.
Satellite DNAs comprise the major component of the Triatoma rubrofasciata repeatome, highlighting their central role in genome composition and architecture. Satellite DNA families show recent amplification in heterochromatin and older, more divergent satellite DNAs located in euchromatin, indicating distinct evolutionary histories.
Sebastián Pita, Pablo Mora, José M. Rico‐Porras, Diogo C. Cabral‐de‐Mello, Francisco J. Ruiz‐Ruano, Teresa Palomeque, Ho Viet Hieu, Francisco Panzera, Pedro Lorite   +8 more
wiley   +1 more source

Rumex acetosa Y chromosomes: constitutive or facultative heterochromatin?

Folia Histochemica et Cytobiologica, 2011
Condensed Y chromosomes in <i>Rumex acetosa</i> L. root-tip nuclei were studied using 5-azaC treatment and immunohistochemical detection of methylated histones. Although Y chromosomes were decondensed within root meristem in vivo, they became
Andrzej J. Joachimiak, Maria Moś, Janusz Malarz, Paweł Pasierbek, Magdalena Mosiołek   +4 more
doaj   +1 more source

Establishment of transgenic Drosophila suzukii lines that express phiC31 integrase and carry the sepia gene as a marker for transformation

Insect Molecular Biology, EarlyView.
Germline transformation of the Drosophila suzukii se1 strain with the wild‐type sepia gene (~1.8 kb) using a piggyBac vector. Most lines show full rescue of sepia mutant eye colour. The lines express phage phiC31 integrase in the germline using a Dsnanos promoter.
Kalindu Ramyasoma Hewawasam, Akihiko Yamamoto, Maxwell J. Scott   +2 more
wiley   +1 more source

Nde1 is required for heterochromatin compaction and stability in neocortical neurons

iScience, 2022
Summary: The NDE1 gene encodes a scaffold protein essential for brain development. Although biallelic NDE1 loss of function (LOF) causes microcephaly with profound mental retardation, NDE1 missense mutations and copy number variations are associated with
Alison A. Chomiak, Yan Guo, Caroline A. Kopsidas, Dennis P. McDaniel, Clara C. Lowe, Hongna Pan, Xiaoming Zhou, Qiong Zhou, Martin L. Doughty, Yuanyi Feng   +9 more
doaj  

The distribution pattern of 5-methylcytosine in rye (Secale L.) chromosomes.

PLoS ONE, 2020
The rye (Secale L.) genome is large, and it contains many classes of repetitive sequences. Secale species differ in terms of genome size, heterochromatin content, and global methylation level; however, the organization of individual types of sequences in
Anna Kalinka, Magdalena Achrem
doaj   +1 more source

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons [PDF]

, 2016
open access articleHerpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced.
Coleman, Heather M., Connor, Viv, Efstathiou, Stacey, Hann, William, Harman, Laura E.R., Nicoll, Michael P., Proenca, Joao T., Shivkumar, Maitreyi   +7 more
core   +3 more sources

Transcriptional gene fusions via targeted integration at safe harbors for high transgene expression in Chlamydomonas reinhardtii

New Phytologist, EarlyView.
Summary Conventional genetic engineering in green microalgae employs error‐prone nonhomologous end joining to integrate recombinant DNA at double‐strand breaks generated at random positions across the nuclear genome. This typically results in variable transcription strength and requires a labor‐intensive screening procedure to identify transformants ...
Nick Jacobebbinghaus, Florian Bigge, Merve Saudhof, Wolfgang Hübner, Olaf Kruse, Thomas Baier   +5 more
wiley   +1 more source

Satellite DNA sites in four species of the genus Astyanax (Teleostei, Characiformes)

Genetics and Molecular Biology, 2007
Cytogenetic data about satellite DNA distribution in four Astyanax species (Characidae) from the Paraitinga river, Paraíba do Sul river basin, Brazil, are presented. In order to characterize the constitutive heterochromatin, C-banding, chromomycin A3 and
Karine Frehner Kavalco, Rubens Pazza, Luiz Antonio Carlos Bertollo, Orlando Moreira-Filho   +3 more
doaj   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source