Results 111 to 120 of about 25,717 (206)
Epigenetics & Chromatin, 2009 Background Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that show variegation of the eye color ...
Vogel Maartje J +5 more
doaj +1 more source
Karyological Characterization of the Endemic Iberian Rock Lizard, Iberolacerta Monticola (Squamata, Lacertidae): Insights into Sex Chromosome Evolution [PDF]
, 2013 [Abstract] Rock lizards of the genus Iberolacerta constitute a promising model to examine the process of sex chromosome evolution, as these closely related taxa exhibit remarkable diversity in the degree of sex chromosome differentiation with no clear ...
Caputo Barucchi, Vincenzo +8 more
core +2 more sources
A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery
Aging Cell, Volume 25, Issue 2, February 2026.This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng +14 more
wiley +1 more source
NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin
Cell ReportsSummary: Heterochromatin exerts pivotal functions of silencing specific genes and maintenance of genome stability. However, its formation and maintenance mechanisms remain unclear.
Yao Wang +12 more
doaj +1 more source
Cell Reports, 2019 Summary: In eukaryotic genomes, heterochromatin is targeted by RNAi machinery and/or by pathways requiring RNA elimination and transcription termination factors.
Tommy V. Vo +8 more
doaj +1 more source
Cancer Science, Volume 117, Issue 2, Page 429-444, February 2026.The present study revealed for the first time that TGM2 could regulate the radiosensitivity of cervical cancer via POGZ‐mediated DNA DSB repair. Our findings revealed that TGM2 regulates the radiosensitivity of cervical cancer and demonstrated that POGZ serves as a bridge linking TGM2 to the DNA damage repair process, and suggested a novel mechanistic ...
Yunbo Chi +5 more
wiley +1 more source
Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast. [PDF]
Commun Biol, 2023 Yamamoto T, Asanuma T, Murakami Y.
europepmc +1 more source
Cell Proliferation, Volume 59, Issue 2, February 2026.The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu +5 more
wiley +1 more source
HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin. [PDF]
Nucleic Acids Res, 2023 Ballmer D +7 more
europepmc +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source