Results 141 to 150 of about 45,751 (265)

Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
With extended lifespans causing population aging, bone aging has become a worldwide issue. Cellular senescence in the bone microenvironment causes bone degeneration and dysfunction. This review summarises targets in cellular senescence and bone aging while detailing potential therapeutic strategies, including novel medicines and innovative biomedical ...
Qiyue Zhu, Menglong Hu, Likun Wu, Erfan Wei, Xingtong Pan, Hao Liu, Yunsong Liu   +6 more
wiley   +1 more source

HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin. [PDF]

Nucleic Acids Res, 2023
Ballmer D, Tardat M, Ortiz R, Graff-Meyer A, Ozonov EA, Genoud C, Peters AH, Fanourgakis G.   +7 more
europepmc   +1 more source

Constitutive heterochromatin and karyotype variation in Indian pygmy mouse, Mus dunni [PDF]

, 1975
T. Sharma, Gaurav Garg
openalex   +1 more source

Fluctuations in DNA Packing Density Drive the Spatial Segregation between Euchromatin and Heterochromatin [PDF]

arXiv
In the crowded eukaryotic nucleus, euchromatin and heterochromatin segregate into distinct compartments, a phenomenon often attributed to homotypic interactions mediated by liquid liquid phase separation of chromatin associated proteins. Here, we revisit genome compartmentalization by examining the role of in vivo DNA packing density fluctuations ...
arxiv  

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Constitutive heterochromatin in chromosomes of duck hybrids and goose hybrids

Poultry Science, 2017
Constitutive heterochromatin is a highly condensed fraction of chromatin in chromosomes. It is characterized by a high degree of polymorphism. Heterochromatin is located in the centromeric, telomeric, and interstitial parts of chromosomes. We used the CBG ( C: banding using B: arium hydroxide by G: iemsa) staining technique to identify heterochromatin ...
E. Wójcik, E. Smalec
openaire   +3 more sources

Comparative cytogenetics in different populations of the cavernicolous diplopod Pseudonannolene strinatii (Diplopoda, Pseudonannolenidae)

Iheringia: Série Zoologia, 2013
Different populations of Pseudonannolene strinatii Mauriès, 1974 collected from three caves in Iporanga, state of São Paulo, were cytogenetically compared using techniques of conventional coloration, C-banding and silver nitrate impregnation.
Kleber A. Campos, Carmem S. Fontanetti
doaj   +1 more source

Mechanisms governing the accessibility of DNA damage proteins to constitutive heterochromatin. [PDF]

Front Genet, 2022
Roemer A, Mohammed L, Strickfaden H, Underhill DA, Hendzel MJ.   +4 more
europepmc   +1 more source

Chromocentres in polymorphs as interphase markers for chromosomes having increased constitutive heterochromatin [PDF]

, 1974
Niels B. Atkin, M.C. Baker
openalex   +1 more source

Active Hydrodynamic Theory of Euchromatin and Heterochromatin [PDF]

arXiv
The genome contains genetic information essential for cell's life. The genome's spatial organization inside the cell nucleus is critical for its proper function including gene regulation. The two major genomic compartments -- euchromatin and heterochromatin -- contain largely transcriptionally active and silenced genes, respectively, and exhibit ...
arxiv