Constitutive heterochromatin formation and transcription in mammals. [PDF]
Epigenetics Chromatin, 2015 Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is believed to ensure a condensed and transcriptionally inert chromatin conformation.
Saksouk N, Simboeck E, Déjardin J.
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Epigenetic Silencing of P-Element Reporter Genes Induced by Transcriptionally Active Domains of Constitutive Heterochromatin in Drosophila melanogaster. [PDF]
Genes (Basel), 2022 Reporter genes inserted via P-element integration into different locations of the Drosophila melanogaster genome have been routinely used to monitor the functional state of chromatin domains.
Messina G +4 more
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Suv39h1 links the SUMO pathway to constitutive heterochromatin. [PDF]
Mol Cell Oncol, 2016 The Suv39h lysine methyltransferases, known as key enzymes responsible for histone H3 lysine 9 methylation, are critical for heterochromatin protein 1 enrichment at constitutive heterochromatin. Our recent findings reveal a new role for the Suv39h1 paralog that links it to SUMO pathway function at constitutive heterochromatin.
Maison C, Quivy JP, Almouzni G.
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The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control [PDF]
Cells, 2022 Constitutive heterochromatin represents a significant fraction of eukaryotic genomes (10% in Arabidopsis, 20% in humans, 30% in D. melanogaster, and up to 85% in certain nematodes) and shares similar genetic and molecular properties in animal and plant ...
Giovanni Messina +4 more
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The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells. [PDF]
J Biol Chem, 2016 Background: BMI1 silences the expression of genes located at the facultative heterochromatin. Results: BMI1 is abundant at repetitive genomic regions, including the pericentromeric heterochromatin (PCH), where it is required for compaction and silencing.
Abdouh M +4 more
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APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. [PDF]
Mol Cell, 2022 Ferguson CJ +20 more
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C-banding, fluorescent staining and NOR location in holokinetic chromosomes of bugs of the Neotropical genus Antiteuchus (Heteroptera: Pentatomidae: Discocephalinae) [PDF]
European Journal of Entomology, 2006 Different cytogenetic techniques including C-banding, base-specific fluorochromes and silver nitrate staining were used to compare the karyotypes of three species of bugs, representatives of the Neotropical genus Antiteuchus, namely A.
Cecilia LANZONE, Maria José DE SOUZA
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Position effect variegation and viability are both sensitive to dosage of constitutive heterochromatin in Drosophila. [PDF]
G3 (Bethesda), 2014 The dosage effect of Y-chromosome heterochromatin on suppression of position effect variegation (PEV) has long been well-known in Drosophila. The phenotypic effects of increasing the overall dosage of Y heterochromatin have also been demonstrated ...
Berloco M +4 more
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The nuclear poly(A)-binding protein Pab2/PABPN1 promotes heterochromatin assembly through the formation of Pab2 nuclear condensates. [PDF]
PLoS GeneticsThe assembly of constitutive heterochromatin is a prerequisite for maintaining genome stability. However, the mechanism of heterochromatin formation has yet to be completely understood.
Ziyue Liu +3 more
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Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin [PDF]
Nucleic Acids Research, 2011 The replication of the genome is a spatio-temporally highly organized process. Yet, its flexibility throughout development suggests that this process is not genetically regulated.
Corella S. Casas-Delucchi +8 more
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