A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types [PDF]
PLoS ONE 8(9): e73818, 2013 Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it. Histone proteins are implicated in the regulation of eukaryote genes and they carry numerous reversible post-translational modifications
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The FEBS Journal, 2019 Constitutive heterochromatin has been canonically considered as transcriptionally inert chromosomal regions, which silences the repeats and transposable elements (TEs), to preserve genomic integrity.
Parna Saha, R. Mishra
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Science Advances, 2023 Programmed constitutive heterochromatin silencing is essential for eukaryotic genome regulation, yet the initial step of this process is ambiguous.
Jincong Zhou +9 more
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Sequence-dependent heterochromatin formation in the human malaria parasite Plasmodium falciparum
Heliyon, 2023 The human malaria parasite Plasmodium falciparum represses transcription of the gene encoding AP2-G, which is the master regulator of germ cell differentiation, via heterochromatin condensation following histone H3 lysine 9 trimethylation (H3K9me3 ...
Toshiyuki Mori, Mai Nakashima
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Comparative Cytogenetics, 2017 Species in the subgenus Artibeus Leach, 1821 are widely distributed in Brazil. Conserved karyotypes characterize the group with identical diploid number and chromosome morphology.
Érica Martinha Silva de Souza +4 more
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SUV39 SET domains mediate crosstalk of heterochromatic histone marks
eLife, 2021 The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin.
Alessandro Stirpe +7 more
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The basal level of gene expression associated with chromatin loosening shapes Waddington landscapes and controls cell differentiation [PDF]
J. Mol. Biol. 432 (2020) 2253-2270, 2020 The baseline level of transcription, which is variable and difficult to quantify, seriously complicates the normalization of comparative transcriptomic data, but its biological importance remains unappreciated. We show that this currently neglected ingredient is essential for controlling gene network multistability and therefore cellular ...
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Epigenetic plasticity safeguards heterochromatin configuration in mammals
Nucleic Acids Research, 2023 Heterochromatin is a key architectural feature of eukaryotic chromosomes critical for cell type-specific gene expression and genome stability. In the mammalian nucleus, heterochromatin segregates from transcriptionally active genomic regions and exists ...
Kei Fukuda +15 more
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A maximum-entropy model to predict 3D structural ensembles of chromatins from pairwise distances: Applications to Interphase Chromosomes and Structural Variants [PDF]
, 2022 The principles that govern the organization of genomes, which are needed for a deeper understanding of how chromosomes are packaged and function in eukaryotic cells, could be deciphered if the three-dimensional (3D) structures are known. Recently, single-cell imaging experiments have determined the 3D coordinates of a number of loci in a chromosome ...
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A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells [PDF]
Biochim Biophys Acta. Gene Regulatory Mechanisms 2017
Feb;1860(2):184-195, 2017 Despite their dynamic nature, certain chromatin marks must be maintained over the long term. This is particulary true for histone 3 lysine 9 (H3K9) trimethylation, that is involved in the maintenance of healthy differentiated cellular states by preventing inappropriate gene expression, and has been recently identified as the most efficient barrier to ...
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