Results 51 to 60 of about 25,717 (206)

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

The Possible Association between Constitutive Heterochromatin Polymorphism and Human Leukemias [PDF]

Cell Journal, 2007
Objective: Polymorphism of the size of heterochromatin region of chromosomes has been well documented in human genome and it consists of DNA sequences that are not transcribed.
Abolfazl Movafagh, Maryam Hajiseyed Javadi, Nahid Arian, Behrooz Katoozian   +3 more
doaj  

HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats. [PDF]

PLoS ONE, 2011
H3 lysine 9 trimethylation (H3K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin.
Kerstin Mosch, Henriette Franz, Szabolcs Soeroes, Prim B Singh, Wolfgang Fischle   +4 more
doaj   +1 more source

Silencing markers are retained on pericentric heterochromatin during murine primordial germ cell development [PDF]

, 2017
Background: In the nuclei of most mammalian cells, pericentric heterochromatin is characterized by DNA methylation, histone modifications such as H3K9me3 and H4K20me3, and specific binding proteins ...
Baarends, W.M. (Willy), Cappellen, W.A. (Gert) van, Eijpe, M. (Maureen), Gribnau, J.H. (Joost), Heijden, G.W. (Godfried) van der, Magaraki, A.M. (Aristea), Magarakis, L. (Leonidas), Peters, A.H.F.M. (Antoine H. F. M.), Sleddens-Linkels, E. (Esther)   +8 more
core   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Cytogenetic studies in four cultivated Amaranthus (Amaranthaceae) species

Comparative Cytogenetics, 2013
In the present study, the chromosomes numbers were confirmed, 2n = 34 for Amaranthus cruentus Linnaeus, 1759, and 2n = 32 for A. hypochondriacus Linnaeus, 1753, A. mantegazzianus Passer, 1864, and A. caudatus Linnaeus, 1753.
Marisa Bonasora, Lidia Poggio, Eduardo Greizerstein   +2 more
doaj   +1 more source

CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells. [PDF]

PLoS Genetics, 2006
During mammalian development, chromatin dynamics and epigenetic marking are important for genome reprogramming. Recent data suggest an important role for the chromatin assembly machinery in this process. To analyze the role of chromatin assembly factor 1
Martin Houlard, Soizik Berlivet, Aline V Probst, Jean-Pierre Quivy, Patrick Héry, Geneviève Almouzni, Matthieu Gérard   +6 more
doaj   +1 more source

Distribution of chromosome 18 and X centric heterochromatin in the interphase nucleus of cultured human cells [PDF]

, 1990
In situ hybridization of human chromosome 18 and X-specific alphoid DNA-probes was performed in combination with three dimensional (3D) and two dimensional (2D) image analysis to study the interphase distribution of the centric heterochromatin (18c and ...
Agard, Arnoldus, Avivi, Baumann, Belmont, Bennett, Blobel, Borden, Brakenhoff, Brinkley, Comings, Comings, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Devilee, Devilee, Emmerich, Guttenbach, Hadlaczky, Hayflick, Hens, Heslop-Harrison, Hilliker, Hopman, Hopman, Hubert, Johnson, Jovin, Kuhn, Landegent, Langer, Lichter, Lichter, Manuelidis, Manuelidis, Manuelidis, Manuelidis, Mathog, Nederlof, O'Brien, Ochs, Oud, Pinkel, Rappold, Rappold, Rawlins, Rosa, Sachs, Schardin, Schmid, Schroeder, Schwarzacher, Schwarzacher, Stelzer, Vogel, Wijnaendts-van-Resandt, Wollenberg, Yang   +63 more
core   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast

eLife
Eukaryotic cells are constantly exposed to various environmental stimuli. It remains largely unexplored how environmental cues bring about epigenetic fluctuations and affect heterochromatin stability.
Li Sun, Libo Liu, Chunlin Song, Yamei Wang, Quan-wen Jin   +4 more
doaj   +1 more source