Results 61 to 70 of about 12,566 (212)

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Rumex acetosa Y chromosomes: constitutive or facultative heterochromatin?

Folia Histochemica et Cytobiologica, 2011
Condensed Y chromosomes in <i>Rumex acetosa</i> L. root-tip nuclei were studied using 5-azaC treatment and immunohistochemical detection of methylated histones. Although Y chromosomes were decondensed within root meristem in vivo, they became
Andrzej J. Joachimiak, Maria Moś, Janusz Malarz, Paweł Pasierbek, Magdalena Mosiołek   +4 more
doaj   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

New insights into the putative XX/XY sex chromosomal system in blue‐eyed red‐fin pleco Hypostomus soniae (Siluriformes, Loricariidae)

Journal of Fish Biology, EarlyView.
Abstract Blue‐eyed red‐fin pleco Hypostomus soniae (family Loricariidae) presented a putative sex system XX/XY in early stage. Aiming to explore the inter‐populational karyotypic variation and proposed emergence of the XX/XY system, we studied 13 H. soniae individuals (6 males, 7 females) from the Tapajós River.
Luan Aércio Melo Maciel, Renata Coelho Rodrigues Noronha, Bruno Rafael Ribeiro de Almeida, Manoella Gemaque Cavalcante, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka, Luís Reginaldo R. Rodrigues   +6 more
wiley   +1 more source

ZmmiR1432‐ZmCML21‐ZmPMA2 Module Affects Maize Low Phosphate Tolerance via Regulating Organic Acid Secretion

Plant Biotechnology Journal, EarlyView.
ABSTRACT Phosphorus is indispensable in agricultural production. The growing global demand for food necessitates the development of crops with enhanced phosphorus utilisation efficiency. However, the molecular mechanisms coordinating phosphorus utilisation efficiency in plants remain incompletely characterised.
Laming Pei, Yaqing Yang, Zhe Wang, Wencheng Duan, Ning Liu, Zhaohua Ding, Hui Li   +6 more
wiley   +1 more source

A constitutive heterochromatic region shapes genome organization and impacts gene expression in Neurospora crassa

BMC Genomics
Background Organization of the eukaryotic genome is essential for proper function, including gene expression. In metazoans, chromatin loops and Topologically Associated Domains (TADs) organize genes into transcription factories, while chromosomes occupy ...
Andrew T. Reckard, Abhishek Pandeya, Jacob M. Voris, Carlos G. Gonzalez Cruz, Oluwatosin Oluwadare, Andrew D. Klocko   +5 more
doaj   +1 more source

The distribution pattern of 5-methylcytosine in rye (Secale L.) chromosomes.

PLoS ONE, 2020
The rye (Secale L.) genome is large, and it contains many classes of repetitive sequences. Secale species differ in terms of genome size, heterochromatin content, and global methylation level; however, the organization of individual types of sequences in
Anna Kalinka, Magdalena Achrem
doaj   +1 more source

Constitutive Heterochromatin Polymorphisms in Children with Acute Lymphoblastic Leukemia

Pediatric Hematology and Oncology, 1993
The C-band heterochromatin polymorphisms of chromosomes 1, 9, and 16 were studied on peripheral lymphocytes of 67 children with acute lymphoblastic leukemia (ALL) and 50 control individuals. A statistically significant difference between patients and controls was found for large heterochromatin regions (level 3) of chromosomes 1 and 9 (P < 0.001) and ...
TSEZOU, A, KITSIOUTZELI, S, KOSMIDIS, H, PAIDOUSI, K, KATSOUYANNI, K, SINANIOTIS, C   +5 more
openaire   +4 more sources

The Evolution and Origin of Allotetraploid Aegilops geniculata Revealed by the Homoeolog‐Resolved Genome Assembly

Plant Biotechnology Journal, EarlyView.
ABSTRACT Aegilops geniculata Roth is a tetraploid (MgMgUgUg; 2n = 4x = 28) wild relative of wheat and a valuable source of genetic diversity for improving agronomic traits. We present a high‐quality homoeolog‐resolved assembly and annotation of the Ae.
Ural Yunusbaev, Gabriela Romero Campos, Rajendran Sathishraj, Evgenii Liakh, John W. Raupp, Aleksey V. Zimin, Alina Akhunova, Dal‐Hoe Koo, Eduard Akhunov   +8 more
wiley   +1 more source