Results 61 to 70 of about 25,717 (206)

MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line.

PLoS ONE, 2012
The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order ...
Bianca Bertulat, Maria Luigia De Bonis, Floriana Della Ragione, Anne Lehmkuhl, Manuela Milden, Christian Storm, K Laurence Jost, Simona Scala, Brian Hendrich, Maurizio D'Esposito, M Cristina Cardoso   +10 more
doaj   +1 more source

Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3-H4 histones and lamin-B receptor [PDF]

, 2015
Diverting a protein from its intracellular location is a unique property of intrabodies. To interfere with the intracellular traffic of heterochromatin protein 1β (HP1β) in living cells, we have generated a cytoplasmic targeted anti-HP1β intrabody ...
Ainsztein, Akhtar, Alessio Cardinale, Aucott, Bannister, Billur, Biocca, Brown, Bult, Butler, Canzio, Cardinale, Cardinale, Cardinale, Cheutin, Chiti, Cohen, Cowell, Dialynas, Filesi, Filesi, Griffin, Hawkins, Horsley, Ilaria Filesi, Jannot, Jenuwein, Jones, Kirilyuk, Kourmouli, Krebber, Kvam, Lachner, Lavigne, Lechner, Lee, Lener, Lo, Luijsterburg, Mateos-Langerak, Meehan, Minc, Monneret, Muchardt, Nakayama, Nishibuchi, Olins, Olzscha, Orlandi, Ostermeier, Peric-Hupkes, Persic, Poleshko, Polioudaki, Prim B. Singh, Rajpal, Sblattero, Silva, Silvia Biocca, Singh, Smothers, Soria, Taddei, Uversky, Wang, Wreggett, Ye, Ye, Zhang, Zhu   +69 more
core   +1 more source

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]

, 2020
Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David, Beliveau, Brian, Cavalli, Giacomo, KARPEN, Gary H., Lee, Yuh, Martins, Nuno, Ogiyama, Yuki, Wu, C-Ting   +7 more
core   +3 more sources

Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives

Insect Science, EarlyView.
The genetic basis of sex determination in Lepidoptera was discovered in 2014 in the silkworm Bombyx mori. In this model species, the W chromosome‐derived small piRNA called Fem piRNA downregulates the expression of a Z‐linked gene, Masculinizer (Masc), which leads to the default female‐specific splicing of the doublesex gene (dsxF) and thus to female ...
František Marec, Atsuo Yoshido, Arjen E. van′t Hof   +2 more
wiley   +1 more source

Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence

The EMBO Journal
Heterochromatin, a key component of the eukaryotic nucleus, is fundamental to the regulation of genome stability, gene expression and cellular functions.
Jia Xie, Zhao-Ning Lu, Shi-Hao Bai, Xiao-Fang Cui, He-Yuan Lian, Chen-Yi Xie, Na Wang, Lan Wang, Ze-Guang Han   +8 more
doaj   +1 more source

A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin

Frontiers in Cell and Developmental Biology, 2023
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging.
Jessica González, Laia Bosch-Presegué, Laia Bosch-Presegué, Anna Marazuela-Duque, Anna Guitart-Solanes, María Espinosa-Alcantud, Agustín F. Fernandez, Agustín F. Fernandez, Agustín F. Fernandez, Agustín F. Fernandez, Jeremy P. Brown, Juan Ausió, Berta N. Vazquez, Berta N. Vazquez, Prim B. Singh, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Alejandro Vaquero   +19 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

DNA and heterochromatin cycles in male gamete development of Oedogonium

Acta Societatis Botanicorum Poloniae, 2014
In antheridial nuclei of Oedogonium cardiacum (Hass.) Wittr. during male gamete formation, the DNA presynthetic period is shortened, the synthetic and postsynthetic periods are lengthened (G1 - 15%, S - 58%, G2 - 29%) as compared with those in vegetative
S. P. Shpilevaya
doaj   +1 more source

Identification of regions of constitutive heterochromatin and sites of ribosomal DNA (rDNA) in Rhogeessa hussoni (Genoways & Baker, 1996) (Chiroptera; Mammalia; Vespertilionidae)

Caryologia, 2021
There is scarce information about the geographical distribution, biological and cytogenetic data from the Rhogeessa hussoni. This study aims to characterize its chromosome composition through chromosome bandings to visualize regions of constitutive ...
Karina Cassia Faria, Adriano Silva Santos, Adriano Silva Santos   +2 more
doaj   +1 more source

Constitutive Heterochromatin Differentiation and Evolutionary Divergence of Karyotype in Oriental Anopheles (Cellia) [PDF]

, 1988
Analysis of the mitotic karyotype of two clusters of closely related species of oriental Anopheles, the A . balabacensis and A. maculatus complexes, has revealed interspecific differences in the amount and distribution of constitutive heterochromatin,
Baimai, Visut
core