SUV39 SET domains mediate crosstalk of heterochromatic histone marks
The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin.
Alessandro Stirpe+7 more
doaj +1 more source
Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]
FRET analysis of cell lines expressing fluorescently tagged histones on separate nucleosomes demonstrates that variations in chromosome compaction occur during ...
Angus I. Lamond+52 more
core +4 more sources
Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi+56 more
core +1 more source
Epigenetic plasticity safeguards heterochromatin configuration in mammals
Heterochromatin is a key architectural feature of eukaryotic chromosomes critical for cell type-specific gene expression and genome stability. In the mammalian nucleus, heterochromatin segregates from transcriptionally active genomic regions and exists ...
Kei Fukuda+15 more
semanticscholar +1 more source
CHROMOSOMAL POLYMORPHISMS OF CONSTITUTIVE HETEROCHROMATIN AND INVERSIONS IN DROSOPHILA [PDF]
ABSTRACT A simple technique for preparing mitotic metaphases from a larval ganglion of Drosophila is described. Parallel examination of polytene and metaphase chromosome groups shows that inversion polymorphism in chromosome 3 of D.
openaire +4 more sources
Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]
The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Brulois, Kevin+6 more
core +3 more sources
Meiotic chromosomes obtained from members of the coleopteran subfamilies Rutelinae and Dynastinae were studied using standard and silver nitrate staining, C-banding, base-specific fluorochromes and fluorescent in situ hybridization (FISH).
Edgar Bione+3 more
doaj +1 more source
Constitutive heterochromatin reorganization during somatic cell reprogramming [PDF]
Induced pluripotent stem (iPS) cell reprogramming is a gradual epigenetic process that reactivates the pluripotent transcriptional network by erasing and establishing repressive epigenetic marks. In contrast to loci-specific epigenetic changes, heterochromatin domains undergo epigenetic resetting during the reprogramming process, but the effect on the ...
E. Fussner+8 more
semanticscholar +5 more sources
Distribution of chromosome 18 and X centric heterochromatin in the interphase nucleus of cultured human cells [PDF]
In situ hybridization of human chromosome 18 and X-specific alphoid DNA-probes was performed in combination with three dimensional (3D) and two dimensional (2D) image analysis to study the interphase distribution of the centric heterochromatin (18c and ...
Agard+63 more
core +1 more source
Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]
Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David+7 more
core +2 more sources