Results 71 to 80 of about 346,273 (274)
Silencing markers are retained on pericentric heterochromatin during murine primordial germ cell development [PDF]
, 2017 Background: In the nuclei of most mammalian cells, pericentric heterochromatin is characterized by DNA methylation, histone modifications such as H3K9me3 and H4K20me3, and specific binding proteins ...
Baarends, W.M. (Willy) +8 more
core +1 more source
Advanced Biology, EarlyView.The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez +8 more
wiley +1 more source
HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats. [PDF]
PLoS ONE, 2011 H3 lysine 9 trimethylation (H3K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin.
Kerstin Mosch +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
The Possible Association between Constitutive Heterochromatin Polymorphism and Human Leukemias [PDF]
Cell Journal, 2007 Objective: Polymorphism of the size of heterochromatin region of chromosomes has been well documented in human genome and it consists of DNA sequences that are not transcribed.
Abolfazl Movafagh +3 more
doaj
Cytogenetic studies in four cultivated Amaranthus (Amaranthaceae) species
Comparative Cytogenetics, 2013 In the present study, the chromosomes numbers were confirmed, 2n = 34 for Amaranthus cruentus Linnaeus, 1759, and 2n = 32 for A. hypochondriacus Linnaeus, 1753, A. mantegazzianus Passer, 1864, and A. caudatus Linnaeus, 1753.
Marisa Bonasora +2 more
doaj +1 more source
CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells. [PDF]
PLoS Genetics, 2006 During mammalian development, chromatin dynamics and epigenetic marking are important for genome reprogramming. Recent data suggest an important role for the chromatin assembly machinery in this process. To analyze the role of chromatin assembly factor 1
Martin Houlard +6 more
doaj +1 more source
The changing role of cell culture in the generation of transgenic livestock [PDF]
, 1999 Transgenesis may allow the generation of farm animals with altered phenotype, animal models for research and animal bioreactors. Although such animals have been produced, the time and expense involved in generating transgenic livestock and then ...
Farini, E, Webster, J, Whitelaw, C B
core +1 more source
Advanced Materials, EarlyView.Integration of computational and experimental approaches for deciphering the underlying mechanism of biomolecular condensates and potential biomaterials design (Created in Biorender. Raza, Z. (2025) https://BioRender.com/irgmeqi). Abstract Biomolecular condensates, a ubiquitous class of biomaterials found in living cells, have been shown to be ...
Qiang Zhu +10 more
wiley +1 more source
A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin
Frontiers in Cell and Developmental Biology, 2023 Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging.
Jessica González +19 more
doaj +1 more source