Results 71 to 80 of about 45,751 (265)

MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line.

PLoS ONE, 2012
The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order ...
Bianca Bertulat, Maria Luigia De Bonis, Floriana Della Ragione, Anne Lehmkuhl, Manuela Milden, Christian Storm, K Laurence Jost, Simona Scala, Brian Hendrich, Maurizio D'Esposito, M Cristina Cardoso   +10 more
doaj   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast

eLife
Eukaryotic cells are constantly exposed to various environmental stimuli. It remains largely unexplored how environmental cues bring about epigenetic fluctuations and affect heterochromatin stability.
Li Sun, Libo Liu, Chunlin Song, Yamei Wang, Quan-wen Jin   +4 more
doaj   +1 more source

DNA and heterochromatin cycles in male gamete development of Oedogonium

Acta Societatis Botanicorum Poloniae, 2014
In antheridial nuclei of Oedogonium cardiacum (Hass.) Wittr. during male gamete formation, the DNA presynthetic period is shortened, the synthetic and postsynthetic periods are lengthened (G1 - 15%, S - 58%, G2 - 29%) as compared with those in vegetative
S. P. Shpilevaya
doaj   +1 more source

Targeting and regulatory mechanisms in chromosome-wide gene regulation using Drosophila melanogaster as a model organism [PDF]

, 2010
Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010O cromossoma 4 de Drosophila melanogaster é muito heterocromático, sendo rico em DNA satélite e DNA de elementos transposáveis. Apesar das suas
Figueiredo, Ana Margarida Adónis, 1986-
core  

Cell nucleus elastography with the adjoint-based inverse solver [PDF]

Computer Methods and Programs in Biomedicine, In press, 2023
Background and Objectives: The mechanics of the nucleus depends on cellular structures and architecture, and impact a number of diseases. Nuclear mechanics is yet rather complex due to heterogeneous distribution of dense heterochromatin and loose euchromatin domains, giving rise to spatially variable stiffness properties.
arxiv  

Constraints on effective constitutive parameters of certain bianisotropic laminated composite materials [PDF]

Electromagnetics, 29:508-514, 2009, 2008
When the electrically thin unit cell of a laminated composite material is made of two bianisotropic sheets whose constitutive properties in the thickness direction are decoupled from the constitutive properties in the interfacial planes, the laminated composite material can be homogenized into a material not all of whose constitutive parameters are ...
arxiv   +1 more source

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

Targets of histone H3 lysine 9 methyltransferases

Frontiers in Cell and Developmental Biology, 2022
Histone H3 lysine 9 di- and trimethylation are well-established marks of constitutively silenced heterochromatin domains found at repetitive DNA elements including pericentromeres, telomeres, and transposons. Loss of heterochromatin at these sites causes
Aidan J. Levinsky, Aidan J. Levinsky, Gregor McEdwards, Gregor McEdwards, Nasha Sethna, Nasha Sethna, Mark A. Currie, Mark A. Currie   +7 more
doaj   +1 more source

Karyotype evolution in progress: A new diploid number in Belostoma candidulum (Heteroptera: Belostomatidae) from Argentina leading to new insights into its ecology and evolution [PDF]

, 2014
A novel chromosome complement (2n = 14 = 12 + XY/XX; male/female sex chromosomes), male meiosis behaviour, heterochromatin characterization, and frequency and distribution of chiasmata are described for the first time in specimens from a natural ...
Bressa, Maria Jose, Chirino, Monica Gabriela   +1 more
core   +1 more source