Results 41 to 50 of about 736,297 (294)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Metals, 2022 The tensile, creep, fatigue and creep-fatigue tests of the nickel-based superalloy GH4169 were carried out. According to the deformation characteristics of GH4169 alloy, the Ohno-Karim kinematic model (O-K model) can be used to describe the tensile ...
Xuteng Hu +4 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Finite-strain formulation and FE implementation of a constitutive model for powder compaction
, 2014 A finite-strain formulation is developed, implemented and tested for a constitutive model capable of describing the transition from granular to fully dense state during cold forming of ceramic powder.
Bigoni, D. +2 more
core +1 more source
Visco-elastic regularization and strain softening [PDF]
, 2006 In this paper it is intended to verify the capacity of regularization of the numerical solution of an elasto-plastic problem with linear strain softening. The finite element method with a displacement approach is used.
Cardoso, R., Silva, V. D., Varum, H.
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Jixie qiangdu, 2018 According to the dual physical characteristics of the steel wire and the rubber possessed by the rubber conveyor belt with the steel wire core,the constitutive model of the entire conveyor belt is obtained by combining the constitutive model of the steel
CHEN HongYue +3 more
doaj
Determination accuracy enhancement of viscoelastic constitutive model of optical glass
Materials & Design, 2023 This study proposes an effective method for improving the determination accuracy of the viscoelastic constitutive model via the combination of uniaxial creep with stress relaxation and the use of creep data to correct stress relaxation curves, known as ...
Guangyu Liu, Fengzhou Fang
doaj +1 more source