Results 61 to 70 of about 257,652 (258)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

STUDY ON TWO-SCALE UNIFIED CONSTITUTIVE MODEL AND DAMPING MECHANISM OF RUBBER CONVEYOR BELT WITH STEEL WIRE ROPE CORE

Jixie qiangdu
Constitutive analysis of steel wire rope conveyor belt is a key problem for conveyor belt design optimization and energy conservation. Maxwell model and Burgers model based on viscoelastic theory and transient dynamics were constructed.
LI Jiangang, FENG Jinping, WANG Xin, LIU Siyuan, GAO Zhongjie, WU Jianjun   +5 more
doaj   +2 more sources

Numerical investigations on constitutive model parameters of HRB400 and HTRB600 steel bars based on tensile and fatigue tests

Reviews on Advanced Materials Science
In recent years, HRB400 and HTRB600 steel bars have become the mainstream standard reinforcing steel used in concrete structures in China. However, significant controversy still exists regarding the selection of material constitutive models and the ...
Zhu Hanbo, Deng Jibing, Zhuang Mei-Ling, Sun Chuanzhi, Gao Li, Shao Yuefeng, Wang Mingsen, Wang Youzhi, Dong Yao-Rong, Tong Lei   +9 more
doaj   +1 more source

Research on M-Paul Dynamic Constitutive Relation of Q235B Steel

Advances in Civil Engineering, 2019
In recent years, terrorist attacks and regional conflicts have increased and research on the resistance of building structures has been more highlighted. Q235B is a commonly used steel type in building structures, and there is an urgent need for research
Li Lin, Bo Huang, Xinke Xiao, Minyuan Huang, Zhiying Liu   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Compressive damage constitutive model for brittle coal based on the compaction effect and linear energy dissipation law

International Journal of Coal Science & Technology
The study of the mechanical property and damage state of coal materials under compression is a fundamental area of research in underground mining engineering. Drawing upon the compaction effect and linear energy dissipation (LED) law, a novel compressive
Fengqiang Gong, Lei Xu, Mingzhong Gao, Yingjie Zhao, Peilei Zhang   +4 more
doaj   +1 more source

FUsion-based ConstitutivE model (FuCe): Towards model-data augmentation in constitutive modelling

CoRR
Constitutive modelling is crucial for engineering design and simulations to accurately describe material behavior. However, traditional phenomenological models often struggle to capture the complexities of real materials under varying stress conditions due to their fixed forms and limited parameters.
Tushar, Sawan Kumar, Souvik Chakraborty
openaire   +2 more sources

The Commonwealth constitutional model or models? [PDF]

International Journal of Constitutional Law, 2013
Stephen Gardbaum’s The New Commonwealth Model of Constitutionalism is a must-read in the growing literature on comparative constitutional law and deserves a broad international audience. My question is whether there is a single Commonwealth constitutional model, or, in reality, a set of Commonwealth constitutional models which share common features ...
openaire   +1 more source