Results 81 to 90 of about 13,942,741 (235)
Constitutive Modelling of Skin Ageing [PDF]
, 2019 The objective of this chapter is to review the main biomechanical and structural aspects associated with both intrinsic and extrinsic skin ageing, and to present potential research avenues to account for these effects in mathematical and computational models of the skin. This will be illustrated through recent work of the authors which provides a basis
Limbert, Georges +2 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Constitutive modeling of the anisotropic behavior of Mullins softened filled rubbers [PDF]
, 2012 Original constitutive modeling is proposed for filled rubber materials in order to capture the anisotropic softened behavior induced by general non-proportional pre-loading histo-ries.
DIANI, Julie +3 more
core +1 more source
A damage-based constitutive model for rock under impacting load
International Journal of Mining Science and Technology, 2014 Using the Splitting Hopkinson Pressure Bar (SHPB) experimental system, investigations were made into the dynamic mechanical performances of underground soft rocks.
Guangming Zhao +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Constitutive model for large strain deformation of semicrystalline polymers [PDF]
, 2006 A constitutive model for large strain deformation of semicrystalline polymers has been formulated to predict the complex elasto-viscoelastic-viscoplastic material response.
Holmes, D.W. +4 more
core +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
, 2008 In presenting a non-linear constitutive model for magneto-sensitive rubber in the frequency range, the influences of dynamic amplitude, frequency and magnetic field are investigated.
Kari, Leif,, Blom, Peter,
core +5 more sources