Results 91 to 100 of about 24,734,390 (300)

Comparison of phenomenological and physical-based constitutive material models for Cr17Mn17Mo3NiN low nickel stainless steel

Materials Research Express
Phenomenological and physical-based constitutive models for the Cr17Mn17Mo3NiN low nickel stainless steel were developed based on the true stress–strain curves acquired from isothermal uniaxial compression tests.
Gun Song Jang, Kyong Ho Sim
doaj   +1 more source

Ballistic Performance of Thermoplastic Fiber-Reinforced Metal Laminates Subjected to Impact Loadings

Applied Sciences
This paper aims to predict the damage and fracture behavior of thermoplastic fiber-reinforced metal laminates (TFMLs) under ballistic impact loadings.
Yan Zeng, Chunguang Li, Hong Zheng, Yijun Liu   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

On the selection of Johnson-Cook constitutive model parameters for Ti-6Al-4V using three types of numerical models of orthogonal cutting

, 2015
Johnson-Cook constitutive model is still the most used model in metal cutting simulation, although several drawbacks reported in the literature. A high number of Johnson-Cook model parameters can be found in the literature for the same work material. One
Yancheng Zhang, J. Outeiro, Tarek Mabrouki   +2 more
semanticscholar   +1 more source

Arrhenius constitutive model of FV520B steel

Metalurgija
To investigate the thermoplastic deformation behavior of FV520B steel, the Gleeble-3800 thermal simulation test machine is used to perform hot compression test on FV520B steel. Select a deformation temperature of 900 °C - 1 050 °C, set the strain rate to
J. Deng, L. W. Chen, B. Y. Cui, Y. P. Li, H. C. Ji   +4 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Variable-parameter constitutive model construction of GH4065 superalloy by considering strain

Journal of Aeronautical Materials
In order to study the high-temperature deformation behavior and constitutive relationship of GH4065 superalloy，high-temperature compression experiments are implemented on GH4065 superalloy.
ZHANG Haoqiang, CAI Liu, JIANG Bingchun, PENG Peiming, TANG Lianyao   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source