Results 101 to 110 of about 24,902,874 (336)

Compressive damage constitutive model for brittle coal based on the compaction effect and linear energy dissipation law

International Journal of Coal Science & Technology
The study of the mechanical property and damage state of coal materials under compression is a fundamental area of research in underground mining engineering. Drawing upon the compaction effect and linear energy dissipation (LED) law, a novel compressive
Fengqiang Gong, Lei Xu, Mingzhong Gao, Yingjie Zhao, Peilei Zhang   +4 more
doaj   +1 more source

A unified creep-plasticity model suitable for thermo-mechanical loading [PDF]

An experimentally based unified creep-plasticity constitutive model was implemented for 1070 steel. Accurate rate and temperature effects were obtained for isothermal and thermo-mechanical loading by incorporating deformation mechanisms into the ...
Sehitoglu, H., Slavik, D.
core   +1 more source

Non-linear modeling of active biohybrid materials [PDF]

, 2012
Recent advances in engineered muscle tissue attached to a synthetic substrate motivates the development of appropriate constitutive and numerical models.
Dorfmann, L., Paetsch, C.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Method to determine the optimal constitutive model from spherical indentation tests

Results in Physics, 2018
The limitation of current indentation theories was investigated and a method to determine the optimal constitutive model through spherical indentation tests was proposed.
Tairui Zhang, Shang Wang, Weiqiang Wang
doaj   +1 more source

T1ρ-based fibril-reinforced poroviscoelastic constitutive relation of human articular cartilage using inverse finite element technology [PDF]

, 2019
BackgroundMapping of T1ρ relaxation time is a quantitative magnetic resonance (MR) method and is frequently used for analyzing microstructural and compositional changes in cartilage tissues.
Alliston, Tamara, Ge, Liang, Hao, Zhixiu, Li, Xiaojuan, Souza, Richard B, Tang, Simon Y, Wan, Chao   +6 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Simulating discontinuities in a gradient-enhanced continuum [PDF]

, 2002
A continuum-discrete model for failure in quasi-brittle materials is presented. The continuum is regularised through the introduction of gradient terms into the constitutive model.
Simone, A, Sluys, LJ, Wells, GN
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

NEML2: An efficient and modular multiphysics constitutive modeling library for hybrid computing environments

SoftwareX
This paper presents NEML2, an open-source, high-performance library developed for constitutive material modeling, designed to support the flexible and modular development of models for complex material behavior.
Tianchen Hu, Mark C. Messner
doaj   +1 more source