Results 71 to 80 of about 24,902,874 (336)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Stress-strain Constitutive Models Along the Grain of Original Bamboo Based on Classification
BioResourcesTo establish the constitutive model of original bamboo, the tensile and compressive tests along the grain of original bamboo were investigated. The original bamboo was graded according to the elastic modulus, and a stress-strain constitutive model of ...
Zhili Cui +3 more
doaj +2 more sources
A Coupled Elastoplastic Damage Dynamic Model for Rock
Shock and Vibration, 2021 Rock dynamic constitutive model plays an important role in understanding dynamic response and addressing rock dynamic problems. Based on elastoplastic mechanics and damage mechanics, a dynamic constitutive model of rock coupled with elastoplastic damage ...
Xuelong Hu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Constitutive modeling for isotropic materials [PDF]
, 1984 The unified constitutive theories for application to typical isotropic cast nickel base supperalloys used for air-cooled turbine blades were evaluated.
Dame, L. T. +3 more
core +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
High Temperature Mechanical Constitutive Modeling of a High-Nb TiAl Alloy
Journal of Aeronautical Materials, 2018 Uniaxial tensile, low cycle fatigue, fatigue-creep interaction and creep experiments of a novel high-Nb TiAl alloy (i.e. Ti-45Al-8Nb-0.2W-0.2B-0.02Y (atom fraction/%)) were conducted at 750℃ to obtain its tested data and curves.
DONG Chengli +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Triaxial tests on frozen ground: formulation and modelling [PDF]
, 2013 Artificial Ground Freezing (AGF) is a controllable process that can be used by engineers to stabilise temporarily the ground, provide structural support and/or exclude groundwater from an excavation until construction of the final lining provides ...
Casini, Francesca +3 more
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