Results 71 to 80 of about 24,734,390 (300)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Numerical investigations on constitutive model parameters of HRB400 and HTRB600 steel bars based on tensile and fatigue tests

Reviews on Advanced Materials Science
In recent years, HRB400 and HTRB600 steel bars have become the mainstream standard reinforcing steel used in concrete structures in China. However, significant controversy still exists regarding the selection of material constitutive models and the ...
Zhu Hanbo, Deng Jibing, Zhuang Mei-Ling, Sun Chuanzhi, Gao Li, Shao Yuefeng, Wang Mingsen, Wang Youzhi, Dong Yao-Rong, Tong Lei   +9 more
doaj   +1 more source

Research on M-Paul Dynamic Constitutive Relation of Q235B Steel

Advances in Civil Engineering, 2019
In recent years, terrorist attacks and regional conflicts have increased and research on the resistance of building structures has been more highlighted. Q235B is a commonly used steel type in building structures, and there is an urgent need for research
Li Lin, Bo Huang, Xinke Xiao, Minyuan Huang, Zhiying Liu   +4 more
doaj   +1 more source

Constitutive Modelling of Skin Ageing [PDF]

, 2019
The objective of this chapter is to review the main biomechanical and structural aspects associated with both intrinsic and extrinsic skin ageing, and to present potential research avenues to account for these effects in mathematical and computational models of the skin. This will be illustrated through recent work of the authors which provides a basis
Limbert, Georges, Pond, Damien, McBride, Andrew   +2 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A constitutive model of frozen saline sandy soil based on energy dissipation theory

, 2016
A series of triaxial compression tests are carried out for frozen saline sandy soil with Na2SO4 contents 0.0, 0.5, 1.5, and 2.5% under confining pressures from 0 MPa to 16 MPa at −6 °C, respectively.
Y. Lai, Mengke Liao, K. Hu
semanticscholar   +1 more source

STUDY ON TWO-SCALE UNIFIED CONSTITUTIVE MODEL AND DAMPING MECHANISM OF RUBBER CONVEYOR BELT WITH STEEL WIRE ROPE CORE

Jixie qiangdu
Constitutive analysis of steel wire rope conveyor belt is a key problem for conveyor belt design optimization and energy conservation. Maxwell model and Burgers model based on viscoelastic theory and transient dynamics were constructed.
LI Jiangang, FENG Jinping, WANG Xin, LIU Siyuan, GAO Zhongjie, WU Jianjun   +5 more
doaj   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Compressive damage constitutive model for brittle coal based on the compaction effect and linear energy dissipation law

International Journal of Coal Science & Technology
The study of the mechanical property and damage state of coal materials under compression is a fundamental area of research in underground mining engineering. Drawing upon the compaction effect and linear energy dissipation (LED) law, a novel compressive
Fengqiang Gong, Lei Xu, Mingzhong Gao, Yingjie Zhao, Peilei Zhang   +4 more
doaj   +1 more source