Results 61 to 70 of about 1,763,243 (270)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Continuum Damage Mechanics—Modelling and Simulation
, 2020 Continuum damage mechanics elaborates the continuum mechanics-based modelling and simulation of mechanical degradation effects. The objective of this contribution is to briefly review different aspects of continuum damage mechanics of solid continua with
Sprave, Leon, +2 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Archives of Civil Engineering, 2011 W artykule przedstawiono model wielopłaszczyznowy (multi-laminate) uwzgledniajacy anizotropie struktury słabonosnych gruntów drobnoziarnistych. Anizotropia indukowana naprezeniem, która otrzymuje sie przy zastosowaniu modeli wielopłaszczyznowych, jest ...
Cundi M.
doaj +1 more source
Peridynamic States and Constitutive Modeling
Journal of Elasticity, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Silling, S. A. +4 more
openaire +2 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Numerical prediction of crack formation in historic masonry buildings
Magazine of Civil EngineeringThis article investigated mechanical behavior of the masonry of historic buildings. It was assumed that reliable cracking processes can be obtained by modeling masonry as a continuous medium and using the Jointed Masonry Model (JMM).
Iovlev Gregorii +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Simulations of Fine-Meshed Biaxial Tests with Barodesy
Geosciences, 2018 Recent experimental studies showed that shear band development starts at the beginning of triaxial tests. In experimental testing, it is impossible to obtain a soil sample with a homogeneous void ratio.
Gertraud Medicus +1 more
doaj +1 more source