Results 71 to 80 of about 1,763,243 (270)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Real-Time Simulation of Tube Hydroforming by Integrating Finite-Element Method and Machine Learning

Journal of Manufacturing and Materials Processing
The real-time, full-field simulation of the tube hydroforming process is crucial for deformation monitoring and the timely prediction of defects. However, this is rather difficult for finite-element simulation due to its time-consuming nature.
Liang Cheng, Haijing Guo, Lingyan Sun, Chao Yang, Feng Sun, Jinshan Li   +5 more
doaj   +1 more source

Constitutive Modelling of Skin Ageing [PDF]

, 2019
The objective of this chapter is to review the main biomechanical and structural aspects associated with both intrinsic and extrinsic skin ageing, and to present potential research avenues to account for these effects in mathematical and computational models of the skin. This will be illustrated through recent work of the authors which provides a basis
Limbert, Georges, Pond, Damien, McBride, Andrew   +2 more
openaire   +2 more sources

Material constitutive behaviour and microstructure study on aluminium alloys for friction stir welding [PDF]

, 2010
The material constitutive behaviour and microstructure of Aluminium alloys 6082 and 7449 were studied with the Gleeble hot compression test. The novel aspect of the work is that the testing was done at high strain-rates and at temperatures within 5 K ...
Colegrove, Paul A., Robson, R. D., Mayer, H. M., Wang, H., Campbell, L.   +4 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

['CONSTITUTIVE MODELLING OF SANDS UNDER MONOTONIC LOADING']

Journal of Mountain Area Research, 2023
Muhammad Safdar, Syed Haseeb Shah, Hamza Ahmad Qureshi, Muhammad Waseem, Khalid Mahmood   +4 more
doaj   +1 more source

Identification of an equivalent model for granular soils by FEM/NMM/p-EMP hybrid system

Computer Assisted Methods in Engineering and Science, 2017
The application of FEM/NMM/p-EMP computational hybrid system in formulation of the Neural Material Model (NMM) for granular soils is presented. NMM is a Multi Layer Preceptron formulated 'on-line'.
Ewa Pabisek
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source