A Review of Mechanical Degradation, Interfacial Nonlinear Dynamics and Multi-Bolt Coupling Degradation Mechanisms of Flange-Bolted Joints. [PDF]
Sensors (Basel)Feng X +8 more
europepmc +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Arbitral functions and constitutive rules
, 2009 It is nowadays widely recognized that constitutive rules play a key role in social ontology. Their definitional character is the primary source of the meaning of every rule-based activity, but what can ensure the persistence of this activity?
Bottazzi, R, E e Ferrario
core
Beyond Primum Non Nocere: Therapeutic Injury, Comparative Harm Management, and the Ethics of Modern Medicine. [PDF]
J Eval Clin PractNikolic B.
europepmc +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Development of Advanced Creep Damage Constitutive Equations for Low CR Alloy Under Long-Term Service [PDF]
Low Cr alloys are mostly utilized in structural components such as steam pipes, turbine generators and reactor pumps operating at high temperatures from 400℃ to 700℃ in nuclear power plants.
Xu, Qihua
core
Groups as institutions: The use of constitutive rules to attribute group membership
Across four experiments we tested children’s (N = 229, aged 4-9) beliefs about what makes an individual a member of a group. One model (groups as institutions) predicts children believe groups are based in constitutive rules, i.e.
Yarrow Dunham, Alexander Noyes
core +1 more source
Machine learning nested in multiphysics finite element analysis: application to flash sintering. [PDF]
J Intell ManufHe R +5 more
europepmc +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source