Results 51 to 60 of about 141,498 (264)

Optimization of nonlinear constrained particle swarm

Technological and Economic Development of Economy, 2006
We propose an algorithm based on the particle swarm paradigm (PSP) to address nonlinear constrained optimization problems. While some algorithms based on PSP have already been proposed in this context, the equality constraints have been posing some ...
António Ismael de Freitas Vaz, Edite Manuela da Graça Pinto Fernandes   +1 more
doaj   +1 more source

A Multi-Strategy Seeker Optimization Algorithm for Optimization Constrained Engineering Problems

IEEE Access, 2022
This paper proposes a multi-strategy seeker optimization algorithm (MSSOA) for optimization constrained engineering problems. In this paper, three strategies were adopted to improve the poor searching capability of the seeker optimization algorithm (SOA).
Shaomi Duan, Huilong Luo, Haipeng Liu
doaj   +1 more source

Distribution‐constrained optimal stopping

Mathematical Finance, 2018
AbstractWe solve the problem of optimal stopping of a Brownian motion subject to the constraint that the stopping time's distribution is a given measure consisting of finitely many atoms. In particular, we show that this problem can be converted to a finite sequence of state‐constrained optimal control problems with additional states corresponding to ...
Bayraktar, Erhan, Miller, Christopher W.
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Convergence rate for diminishing stepsize methods in nonconvex constrained optimization via ghost penalties

Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2020
This is a companion paper to "Ghost penalties in nonconvex constrained optimization: Diminishing stepsizes and iteration complexity" (to appear in Mathematics of Operations Research).
Francisco Facchinei, Vyacheslav Kungurtsev, Lorenzo Lampariello, Gesualdo Scutari   +3 more
doaj   +1 more source

CIOA: Circle-Inspired Optimization Algorithm, an algorithm for engineering optimization

SoftwareX, 2022
This paper presents a new, robust and very efficient metaheuristic optimization algorithm, called Circle Inspired Optimization Algorithm (CIOA), for solving constrained and unconstrained engineering optimization problems. The inspiration for the proposed
Otávio Augusto Peter de Souza, Letícia Fleck Fadel Miguel   +1 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Improved Cuckoo Search (ICS) algorthm for constrained optimization problems

Latin American Journal of Solids and Structures
Constrained optimization is very important issue in engineering design. The problem of constrained optimization contains the objective function with linear and nonlinear constraint equations.
Radovan R. Bulatović, Goran Bošković, Mile M. Savković, Milomir M. Gašić   +3 more
doaj   +1 more source