Results 51 to 60 of about 619,780 (278)

Towards a Lagrange-Newton approach for PDE constrained shape optimization

, 2014
The novel Riemannian view on shape optimization developed in [Schulz, FoCM, 2014] is extended to a Lagrange-Newton approach for PDE constrained shape optimization problems.
A Novruzi, C Schillings, EJ Haug, HB Ameur, J Céa, K Eppler, M Bauer, PW Michor, PW Michor, PW Michor, R Correa, S Schmidt, S Schmidt, VH Schulz   +13 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Exploiting symmetries in SDP-relaxations for polynomial optimization

, 2012
In this paper we study various approaches for exploiting symmetries in polynomial optimization problems within the framework of semi definite programming relaxations.
Barvinok AI, Barvinok AI, Bröcker L, Cordian Riener, Dixon JD, Henrion D, James G, Jean B. Lasserre, Lasserre JB, Lina Jansson Andrén, Serre J-P, The GAP Group, Thorsten Theobald   +12 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Constrained Optimization of MIMO Training Sequences

EURASIP Journal on Advances in Signal Processing, 2007
Multiple-input multiple-output (MIMO) systems have shown a huge potential for increased spectral efficiency and throughput. With an increasing number of transmitting antennas comes the burden of providing training for channel estimation for coherent ...
Coon Justin P, Sandell Magnus
doaj   +2 more sources

Constrained Bayesian Optimization: A Review

IEEE Access
Bayesian optimization is a sequential optimization method that is particularly well suited for problems with limited computational budgets involving expensive and non-convex black-box functions.
Sasan Amini, Inneke Vannieuwenhuyse, Alejandro Morales-Hernandez   +2 more
doaj   +1 more source

CIOA: Circle-Inspired Optimization Algorithm, an algorithm for engineering optimization

SoftwareX, 2022
This paper presents a new, robust and very efficient metaheuristic optimization algorithm, called Circle Inspired Optimization Algorithm (CIOA), for solving constrained and unconstrained engineering optimization problems. The inspiration for the proposed
Otávio Augusto Peter de Souza, Letícia Fleck Fadel Miguel   +1 more
doaj   +1 more source

Modeling and Optimization of Complex Building Energy Systems with Deep Neural Networks

, 2017
Modern buildings encompass complex dynamics of multiple electrical, mechanical, and control systems. One of the biggest hurdles in applying conventional model-based optimization and control methods to building energy management is the huge cost and ...
Chen, Yize, Shi, Yuanyuan, Zhang, Baosen
core   +1 more source