Results 61 to 70 of about 161,542 (309)

Active Exploration by Chance-Constrained Optimization for Voltage Regulation with Reinforcement Learning

open access: yesEnergies, 2022
Voltage regulation in distribution networks encounters a challenge of handling uncertainties caused by the high penetration of photovoltaics (PV). This research proposes an active exploration (AE) method based on reinforcement learning (RL) to respond to
Zhenhuan Ding, Xiaoge Huang, Zhao Liu
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Enhanced Meta-model Based Optimization under Constraints using Parallel Computations [PDF]

open access: yes, 2017
Meta-models proved to be a very efficient strategy for optimization of expensive black-box models, e.g. Finite Element simulation for electromagnetic devices. It enables to reduce the computational burden for optimization purposes.
Stephane Clenet   +8 more
core   +1 more source

Guided Hybrid Modified Simulated Annealing Algorithm for Solving Constrained Global Optimization Problems

open access: yesMathematics, 2022
In this paper, a hybrid gradient simulated annealing algorithm is guided to solve the constrained optimization problem. In trying to solve constrained optimization problems using deterministic, stochastic optimization methods or hybridization between ...
Khalid Abdulaziz Alnowibet   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Constrained Bayesian Optimization: A Review

open access: yesIEEE Access
Bayesian optimization is a sequential optimization method that is particularly well suited for problems with limited computational budgets involving expensive and non-convex black-box functions.
Sasan Amini   +2 more
doaj   +1 more source

Convergence rate for diminishing stepsize methods in nonconvex constrained optimization via ghost penalties

open access: yesAtti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2020
This is a companion paper to "Ghost penalties in nonconvex constrained optimization: Diminishing stepsizes and iteration complexity" (to appear in Mathematics of Operations Research).
Francisco Facchinei   +3 more
doaj   +1 more source

Frameworks and Results in Distributionally Robust Optimization

open access: yesOpen Journal of Mathematical Optimization, 2022
The concepts of risk aversion, chance-constrained optimization, and robust optimization have developed significantly over the last decade. The statistical learning community has also witnessed a rapid theoretical and applied growth by relying on these ...
Rahimian, Hamed, Mehrotra, Sanjay
doaj   +1 more source

Distribution‐constrained optimal stopping

open access: yesMathematical Finance, 2018
AbstractWe solve the problem of optimal stopping of a Brownian motion subject to the constraint that the stopping time's distribution is a given measure consisting of finitely many atoms. In particular, we show that this problem can be converted to a finite sequence of state‐constrained optimal control problems with additional states corresponding to ...
Bayraktar, Erhan, Miller, Christopher W.
openaire   +4 more sources

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

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