Results 81 to 90 of about 161,542 (309)
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
A unified gradient flow approach to constrained nonlinear optimization problems [PDF]
, 2003 This paper presents a unified gradient flow approach to nonlinear constrained optimization problems. This method is based on a continuous gradient flow reformulation of constrained optimization problems and on a two level time discretization of the ...
Yang, XQ +4 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Population Feasibility State Guided Autonomous Constrained Multi-Objective Evolutionary Optimization
MathematicsMany practical problems can be classified as constrained multi-objective optimization problems. Although various methods have been proposed for solving constrained multi-objective optimization problems, there is still a lack of research considering the ...
Mingcheng Zuo, Yuan Xue
doaj +1 more source
A Method for Balancing Provider Schedules in Outpatient Specialty Clinics
MDM Policy & Practice, 2020 Background. Variability in outpatient specialty clinic schedules contributes to numerous adverse effects including chaotic clinic settings, provider burnout, increased patient waiting times, and inefficient use of resources.
Bjorn P. Berg +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
A limited memory BFGS subspace algorithm for bound constrained nonsmooth problems
Journal of Inequalities and Applications, 2020 The subspace technique has been widely used to solve unconstrained/constrained optimization problems and there exist many results that have been obtained. In this paper, a subspace algorithm combining with limited memory BFGS update is proposed for large-
Xiangrong Li
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Zhongguo Jianchuan Yanjiu, 2018 [Objectives] In order to further improve the vibration characteristics of traditional constrained damping structures, the optimized design of an improved constrained stand-off layer damping structure with engineering application value is carried out ...
YI Shaoqiang, HE Shiping, WANG Jie
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source