Results 41 to 50 of about 132,157 (272)

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook   +6 more
wiley   +1 more source

Designing heterogeneous porous tissue scaffolds for additive manufacturing processes [PDF]

open access: yes, 2013
A novel tissue scaffold design technique has been proposed with controllable heterogeneous architecture design suitable for additive manufacturing processes.
Khoda, AKM Bashirul   +4 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

An Electromigration and Thermal Model of Power Wires for a Priori High-Level Reliability Prediction [PDF]

open access: yes, 2004
In this paper, a simple power-distribution electrothermal model including the interconnect self-heating is used together with a statistical model of average and rms currents of functional blocks and a high-level model of fanout distribution and ...
Casu, Mario Roberto   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An Algorithm for Designing Circles in a Bubble Chart

open access: yesAxioms
In this study, we investigated circle design in a bubble chart. The bubble chart that we designed has a unit circle at the center and is surrounded by a series of layered circle rings.
Ching-Shoei Chiang, Hung-Chieh Li
doaj   +1 more source

Linking Quality Attributes and Constraints with Architectural Decisions [PDF]

open access: yes, 2012
Quality attributes and constraints are among the main drivers of architectural decision making. The quality attributes are improved or damaged by the architectural decisions, while restrictions directly include or exclude parts of the architecture (for ...
Ameller, David, Franch, Xavier
core   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Extended General Malfatti’s Problem

open access: yesAlgorithms
Malfatti’s problem involves three circles (called Malfatti circles) that are tangent to each other and two sides of a triangle. In this study, our objective is to extend the problem to find 6, 10, … ∑1ni (n > 2) circles inside the triangle so that the ...
Ching-Shoei Chiang
doaj   +1 more source

Assessment of Quantity Surveying Firms' Process and Product Innovation Drive in Nigeria

open access: yesSEISENSE Journal of Management, 2019
Purpose- Innovation repositions and strengthens the competitive advantage and revenue drive of corporate businesses. The aim of this study is to assess the extent of the process and product innovation in Nigerian Quantity Surveying firms with a view to ...
Onyeagam Onyealilam Peter   +2 more
doaj   +1 more source

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