Results 51 to 60 of about 132,157 (272)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
AerospaceThe low-altitude economy represents an important facet of emerging productive forces, and flying cars serve as key vehicles driving its development. This paper proposes an aerodynamic design for the aerial vehicle module of split-type flying cars, which ...
Songyang Li +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Scientific ReportsThe integration of computer-aided design (CAD), computer-aided process planning (CAPP), and computer-aided manufacturing (CAM) systems is significantly enhanced by employing deep learning-based automatic feature recognition (AFR) methods.
Liuhuan Ma, Jiong Yang
doaj +1 more source
Application of Matlab and Simulink to a Low-Lift Sump System
Measurement + Control, 1992 This paper describes the application of a computer-aided control system design (CACSD) tool known as Simulink. Simulink is a modern non-linear dynamic simulation tool and forms an extension to Matlab,* adding many features specific to dynamic systems ...
Stephen J Pole
doaj +1 more source
Methodology for standard cell compliance and detailed placement for triple patterning lithography [PDF]
, 2013 As the feature size of semiconductor process further scales to sub-16nm technology node, triple patterning lithography (TPL) has been regarded one of the most promising lithography candidates.
Gao, Jhih-Rong +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Multi-objective optimization in plastic injection molding with injection and packing time
Nihon Kikai Gakkai ronbunshu, 2015 Plastic injection molding (PIM) is one of the most important manufacturing processes for producing plastic products. The process parameters in the PIM, such as mold temperature, melt temperature, and injection pressure affect the product quality and the ...
Shinji NATSUME, Satoshi KITAYAMA
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Computer-Aided Conceptual Design Through TRIZ-based Manipulation of Topological Optimizations [PDF]
, 2009 Organised by: Cranfield UniversityIn a recent project the authors proposed the adoption of Optimization Systems [1] as a bridging element between Computer-Aided Innovation (CAI) and PLM to identify geometrical contradictions [2], a particular case of ...
Cascini, G. +3 more
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