Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control
Advanced Science, EarlyView.Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang +9 more
wiley +1 more source
An LLM-Based Framework for the Automatic Generation of SysML Models. [PDF]
Sensors (Basel)An B, Lei T, Tian G.
europepmc +1 more source
Geometry‐Encoded Actuation as a Structural Interaction Layer in Origami Robots
Advanced Science, EarlyView.We present geometry‐encoded actuation (GEA), a design framework that integrates multistable origami with liquid crystal elastomer actuators to encode environmental interactions into autonomous structural responses. GEA enables programmable shape transformation without continuous sensing or complex control, achieving robust adaptive manipulation and ...
Jianshu Zhou +8 more
wiley +1 more source
A Quantum Annealing Approach for Solving Optimal Feature Selection and Next Release Problems. [PDF]
Entropy (Basel)Zhang Y, Wang S, Yang W.
europepmc +1 more source
A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing
Advanced Science, EarlyView.We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song +5 more
wiley +1 more source
GRNN-DP-MPC Co-optimization for predictive energy management in hybrid UAVs. [PDF]
Sci RepKan W, Chen S, Lei W, Ma C, Pan J.
europepmc +1 more source
Advanced Science, EarlyView.An attention‐based multimodal deep learning framework is developed to predict the creep life of Ni‐based superalloys by fusing processing parameters with microstructural micrographs. The model achieves high accuracy (R2 = 0.92), aligns with metallurgical principles by capturing δ‐phase influence, and incorporates uncertainty quantification, offering a ...
Haopeng Lv +10 more
wiley +1 more source
Optimizing multi-level shuttle-based puzzle storage systems with horizontal and vertical dynamics using integer programming and ALNS-IP. [PDF]
Sci RepAl Jneid R, Yiğit V, Keskin ME.
europepmc +1 more source
Advanced Science, EarlyView.A large‐area, noise‐resilient multiplexed triboelectric sensing garment based on a multilayer shielded architecture and SnS2 nanoflower‐engineered hybrid materials enables interference‐suppressed, high‐fidelity full‐body motion tracking, achieving 0.13% signal misrecognition, 57 dB electromagnetic noise attenuation, and >1.5 N threshold force, while ...
Beibei Shao +14 more
wiley +1 more source
A rule-based, feedback-driven framework for fully automated prostate VMAT planning. [PDF]
J Appl Clin Med PhysSangster J +4 more
europepmc +1 more source