Results 31 to 40 of about 3,012,120 (253)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Policy design under institutional constraint: discretion, targeting, and governance infrastructure

Policy Design and Practice
Policy design scholarship rests upon institutional conditions that do not universally obtain: fiscal sovereignty, pluralist accountability, and distributed design authority.
Anis Ben Brik
doaj   +1 more source

Coinductive Constraint Logic Programming [PDF]

, 2012
Constraint logic programming (CLP) has been proposed as a declarative paradigm for merging constraint solving and logic programming. Recently, coinductive logic programming has been proposed as a powerful extension of logic programming for handling (rational) infinite objects and reasoning about their properties.
Neda Saeedloei, Gopal Gupta 0001
openaire   +2 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Folding Transformation Rules for Constraint Logic Programs [PDF]

, 2008
We consider the folding transformation rule for constraint logic programs. We propose an algorithm for applying the folding rule in the case where the constraints are linear equations and inequations over the rational or the real numbers. Basically, our
Senni, Valerio, Pettorossi, Alberto, Proietti, Maurizio   +2 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Visualization designs for constraint logic programming [PDF]

, 2001
We address the design and implementation of visual paradigms for observing the execution of constraint logic programs, aiming at debugging, tuning and optimization, and teaching. We focus on the display of data in CLP executions, where representation for
Hermenegildo, Manuel V., Carro Liñares, Manuel   +1 more
core  

A backward analysis for constraint logic programs [PDF]

Theory and Practice of Logic Programming, 2002
One recurring problem in program development is that of understanding how to re-use code developed by a third party. In the context of (constraint) logic programming, part of this problem reduces to figuring out how to query a program. If the logic program does not come with any documentation, then the programmer is forced to either experiment with
Andy King, Lunjin Lu
openaire   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source