Results 61 to 70 of about 564,271 (287)
Croatian Operational Research Review, 2019 In this paper we investigate a bilevel optimization problem by using the optimistic approach. Under a non smooth generalized Guignard constraint qualification, due the optimal value reformulation, the necessary optimality conditions in terms of ...
Nazih Abderrazzak Gadhi +1 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Nonsingularity Conditions for FB System of Reformulating Nonlinear Second-Order Cone Programming
Abstract and Applied Analysis, 2013 This paper is a counterpart of Bi et al., 2011. For a locally optimal solution to the nonlinear second-order cone programming (SOCP), specifically, under Robinson’s constraint qualification, we establish the equivalence among the following three ...
Shaohua Pan, Shujun Bi, Jein-Shan Chen
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Constraint Design Rewriting [PDF]
, 2013 We propose an algebraic approach to the design and transformation of constraint networks, inspired by Architectural Design Rewriting. The approach can be understood as (i) an extension of ADR with constraints, and (ii) an application of ADR to the design
Lluch-Lafuente, Alberto +2 more
core
Two-Level Optimization Problems with Infinite Number of Convex Lower Level Constraints [PDF]
Control and Optimization in Applied Mathematics, 2017 This paper proposes a new form of optimization problem which is a two-level programming problem with infinitely many lower level constraints. Firstly, we consider some lower level constraint qualifications (CQs) for this problem.
Nader Kanzi
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source