Results 71 to 80 of about 564,271 (287)
Breaking conditional symmetry in automated constraint modelling with CONJURE [PDF]
, 2014 This work was supported by UK EPSRC EP/K015745/1. Jefferson is supported by a Royal Society University Research Fellowship.Many constraint problems contain symmetry, which can lead to redundant search.
Gent, Ian +8 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Constraint Based Planning with Composable Substate Graphs. [PDF]
, 2010 Constraint satisfaction techniques provide powerful inference algorithms that can prune choices during search. Constraint-based approaches provide a useful complement to heuristic search optimal planners.We develop a constraint-based model for cost ...
Fox, Maria, Gregory, Peter, Long, Derek
core +3 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
On constraint qualifications with generalized convexity and optimality conditions [PDF]
This paper deals with a multiobjective programming problem involving both equality constraints in infinite dimensional spaces. It is shown that some constraint qualifications together with a condition of interior points are sufficient conditions for the ...
Do Van Luu, Manh-Hung Nguyen
core
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Constraint Qualification Failure in Action
, 2020 This note presents a theoretical analysis of disjunctive constraints featuring unbounded variables. In this framework, classical modeling techniques, including big-M approaches, are not applicable.
Hassan Hijazi, Leo Liberti
core
Optimality conditions and the basic constraint qualification for quasiconvex programming
, 2011 In this paper, we consider optimality conditions and a constraint qualification for quasiconvex programming. To the purpose, we introduce a generator and a new subdifferential for quasiconvex functions by using Penot and Volle’s ...
Kuroiwa, Daishi, Suzuki, Satoshi
core +2 more sources
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2020 This is a companion paper to "Ghost penalties in nonconvex constrained optimization: Diminishing stepsizes and iteration complexity" (to appear in Mathematics of Operations Research).
Francisco Facchinei +3 more
doaj +1 more source