Results 141 to 150 of about 19,523 (194)

冠不全の外科的治療に関する実験的研究 [PDF]

, 1958
NAKANO, HIROSHI
core  

Exposure to pseudoephedrine during pregnancy and major congenital malformations: Findings from a large population‐based cohort of pregnancies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to assess the risk of major congenital malformations following first‐trimester pseudoephedrine (PSE) exposure. Methods A population‐based observational cohort study was conducted on pregnancies of women aged 15–49 years, insured by Clalit Health Services in southern Israel, who gave birth or had elective ...
Saar Dor, Tal Michael, Yael Levi, Gali Pariente, Eitan Lunenfeld, Amalia Levy, Shira Birenstock‐Cohen, Sharon Daniel   +7 more
wiley   +1 more source

Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson, Joanne Watson, Susan Rosser, Ellie Hawke, Andrew Pitt, Tessa Moses, Leon Pybus, Magnus Rattray, Alan J. Dickson, Jean‐Marc Schwartz   +9 more
wiley   +1 more source

TIMD4^hiMHCⅡ^hi Macrophages Preserve Heart Function Through Retnla. [PDF]

JACC Basic Transl Sci
Zhang D, Wang X, Zhu L, Chen Y, Yang C, Zhong Z, Kong X, Nan J, Wang C, Hu H, Chen J, Shi P, Hu X, Zhu W, Wang J.   +14 more
europepmc   +1 more source

Retinal vascular changes as a diagnostic aid : with special reference to certain hypertensive states [PDF]

, 1942
Dyhrberg, Norman N
core   +1 more source

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Biotechnology and Bioengineering, EarlyView.
This study investigates the temporal effects of galactose and manganese on the N‐glycosylation of Trastuzumab (mAb) antibody during fed‐batch and perfusion bioprocessing modes to reveal the influence of feeding schedules on mAb N‐glycosylation patterns. These findings will aid in building process control schemes for mAb bioprocessing.
Aron Gyorgypal, Erica Fratz‐Berilla, Casey Kohnhorst, David N. Powers, Shishir P. S. Chundawat   +4 more
wiley   +1 more source

Study of blood flow patterns in a stenosed artery through the combined effect of body acceleration and generalized womersley solution. [PDF]

Sci Rep
Udupa MC, Saha S, Natarajan S.
europepmc   +1 more source

Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu, Thais de las Heras Ruiz, Francesca M. Johnson de Sousa Brito, Jamie Soul, Jonathan Coxhead, Matthew J. German, David A. Young, Ana M. Ferreira‐Duarte, Katarzyna A. Piróg   +8 more
wiley   +1 more source

Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress. [PDF]

JACC Basic Transl Sci
Patil M, Singh S, Dubey PK, Tousif S, Umbarkar P, Zhang Q, Lal H, Sewell-Loftin MK, Umeshappa CS, Ghebre YT, Pogwizd S, Zhang J, Krishnamurthy P.   +12 more
europepmc   +1 more source

Techno‐Economic Analysis of Membrane‐Based Purification Platforms for AAV Vector Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Technologies for large‐scale manufacturing of viral vectors for gene therapies, such as tangential flow filtration and membrane chromatography, are under development. In these early stages of process development, techno‐economic analyses are useful for identifying membrane properties yielding the greatest impact on process performance. In this
Juan J. Romero, Eleanor W. Jenkins, Jacob I. Monroe, S. Ranil Wickramasinghe, Xianghong Qian, Dibakar Bhattacharyya, Scott M. Husson   +6 more
wiley   +1 more source