Results 41 to 50 of about 166,584 (312)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Bilateral popliteal entrapment syndrome in a young athlete diagnosed with ultrasound

Radiology Case Reports, 2022
Popliteal artery entrapment syndrome (PAES) occurs when the popliteal artery is compressed by abnormally developed or hypertrophied muscles adjacent to the popliteal fossa.
Hanna K. Thompson, BS, Justin R. Montgomery, MD, Paul J. Spicer, MD   +2 more
doaj   +1 more source

Tuberculous constrictive pericarditis [PDF]

Research in Cardiovascular Medicine, 2015
Constrictive pericarditis is characterized by constriction of the heart secondary to pericardial inflammation. Cardiovascular magnetic resonance (CMR) imaging is useful imaging modality for addressing the challenges of confirming this diagnosis. It can be used to exclude other causes of right heart failure, such as pulmonary hypertension or myocardial ...
Tse, Gary, Ali, Aamir, Alpendurada, Francisco, Prasad, Sanjay, Raphael, Claire E, Vassiliou, Vassilios   +5 more
openaire   +5 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Pericardial Constriction with Severe Mitral Regurgitation: An Uncommon Association

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging, 2020
Pericardial constriction is a condition, in which there is a lack of transmission of changes in intrathoracic pressures to the structures encased in pericardium due to thickened, fibrosed, and most of the cases, calcified pericardium.
Saurabh Ajit Deshpande, A. George Koshy, Mathew Iype, K. Sunitha Viswanathan   +3 more
doaj   +1 more source

Xylem manipulation techniques affecting tree vigour in peach and olive trees

, 2018
Water relations are among the major factors affecting shoot growth and plant vegetative vigor. In many tree crops, dwarfing rootstocks regulate scion vegetative vigor by reducing plant hydraulic conductance. In Prunus spp. reduced xylem vessel size leads
Poni, S., Tombesi, S.
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Constriction of Pulmonary Artery by Peroxide: Role of Ca2+ Release and PKC

, 2008
Reactive oxygen species are implicated in pulmonary hypertension and hypoxic pulmonary vasoconstriction. We examined the effects of low concentrations of peroxide on intrapulmonary arteries (IPA).
Shaifta, Y., Ward, J.P., Knock, Greg A.; id_orcid, Aaronson, Philip I., Snetkov, Vladimir A., Pourmahram, Ghazaleh Esmaeil, Ward, Jeremy P. T., Aaronson, P.I., Snetkov, V.A., Pourmahram, G.E., Drndarski, Svetlana, Drndarski, S., Shaifta, Yasin, Knock, G.A.   +13 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Cell type specificity of neurovascular coupling in cerebral cortex

eLife, 2016
Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of ...
Hana Uhlirova, Kıvılcım Kılıç, Peifang Tian, Martin Thunemann, Michèle Desjardins, Payam A Saisan, Sava Sakadžić, Torbjørn V Ness, Celine Mateo, Qun Cheng, Kimberly L Weldy, Florence Razoux, Matthieu Vandenberghe, Jonathan A Cremonesi, Christopher GL Ferri, Krystal Nizar, Vishnu B Sridhar, Tyler C Steed, Maxim Abashin, Yeshaiahu Fainman, Eliezer Masliah, Srdjan Djurovic, Ole A Andreassen, Gabriel A Silva, David A Boas, David Kleinfeld, Richard B Buxton, Gaute T Einevoll, Anders M Dale, Anna Devor   +29 more
doaj   +1 more source