Directed evolution of enzymes at the crossroads of tradition and innovation
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Uncoupling apical constriction from tissue invagination [PDF]
Apical constriction is a widely utilized cell shape change linked to folding, bending and invagination of polarized epithelia. It remains unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this cellular ...
SeYeon Chung +2 more
core +1 more source
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Contralateral monoarthritis exacerbated chronic constriction injury-induced pain hypersensitivity through upregulating inducible nitric oxide synthase [PDF]
Heng Zhao,1 Shenghou Liu,1 Chenhua Wang,2 Qingjie Wang,3 Wenguang Liu,1 Mingzhi Gong1 1Department of Orthopedics, The Second Hospital of Shandong University, Jinan, 250033, Shandong, People’s Republic of China; 2Department of Nuclear Medicine, The ...
Wang Q +5 more
core
An unusual case of constriction ring dystocia [PDF]
We present here an unusual case of constriction ring dystocia. In the case during intra-partum abdominal contour look like Bandl’s retraction ring but on cesarean section identified the constriction ring of uterine myometrium strangling the fetal ...
Patidar, Arti +3 more
core +2 more sources
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
POSITIVE COLUMN CONSTRICTION IN CESIUM PLASMA DISCHARGE [PDF]
A lot of papers were published by different authors on positive column with the purpose to explain the constriction phenomena. There are niany proposed mechanisms to explain surprisingly well one and the same phenomenon - the positive column ...
N. Niculescu., A. Popescu, G. Musa
core +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
Application of the chronic constriction injury of the partial sciatic nerve model to assess acupuncture analgesia [PDF]
Mu-Jun Zhi,1,2,* Kun Liu,1,* Zhou-Li Zheng,1,3 Xun He,1 Tie Li,2 Guang Sun,1,2 Meng Zhang,4 Fu-Chun Wang,2 Xin-Yan Gao,1 Bing Zhu1 1Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing ...
Liu K +9 more
core
Snoring in individuals with and without maxillary constriction [PDF]
Objective: compare snoring in individuals with and without maxillary constriction. Methods: 124 individuals (mean age, 40.53; SD, 15.59), 81 women and 43 men were evaluated.
Marcos J. Carruitero +2 more
core +1 more source

