Results 41 to 50 of about 1,368,536 (353)

What to Do When Medical Evidence Can Only Be Generated Through Routine Data: An Example From Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children undergoing allogeneic stem cell transplantation often receive off‐label rituximab treatment for Epstein–Barr virus reactivation, using adult dosing without pediatric evidence. This project aims to develop a clinical decision support tool (CDSS) that provides evidence‐based dosing scenarios by analyzing real‐world patient data.
Birgit Burkhardt, Antje Walz, Dietrich Knoerzer   +2 more
wiley   +1 more source

Testing and comparing two self-care-related instruments among older Chinese adults [PDF]

, 2017
OBJECTIVES:The study aimed to test and compare the reliability and validity, including sensitivity and specificity of the two self-care-related instruments, the Self-care Ability Scale for the Elderly (SASE), and the Appraisal of Self-care Agency Scale ...
Ding, Xianfei, Gao, Han, Guo, Lina, Guo, Qiyun, Liu, Kun, Liu, Yanjin, McCallum, Jacqueline, Söderhamn, Ulrika   +7 more
core   +4 more sources

Animal models as tools to study the pathophysiology of depression

Brazilian Journal of Psychiatry, 2013
The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden associated with depression.
Helena M. Abelaira, Gislaine Z. Reus, Joao Quevedo   +2 more
doaj   +1 more source

Study of Validity in Religiosity Measurement Surveys in Iran [PDF]

جامعه شناسی کاربردی, 2016
Introduction Validity is the most important feature of a measure and this feature is the only permission for using the result of study. When research is on topics such as religion, the validity will be even more important. Such concepts like religion are
Hossein Shojaeezand, Alireza Shojaeezand
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Behavioral Regulation Sport Questionnaire: Gender and Sport Invariance in Portuguese Athletes [PDF]

, 2019
Versão depositada: post-printThis study aimed to analyze measurement invariance of the Behavioral Regulation Sports Questionnaire (BRSQ) across the gender and four different sports.
Cid, Luis, Machado, Sérgio, Monteiro, Diogo, Moutão, João, Rodrigues, Filipe, Teixeira, Diogo, Vitorino, Anabela   +6 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

School Alienation: A Construct Validation Study

Frontline Learning Research, 2017
Early identification of school alienation is of great importance for students’ educational outcomes and successful participation in society. This study examined the psychometric characteristics of a newly developed assessment instrument, the School ...
Julia Morinaj, Jan Scharf, Alyssa Grecu, Andreas Hadjar, Tina Hascher, Kaja Marcin   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Translation and Psychometric Evaluation of the Gujarati Version of Participation Scale for Stroke Patients: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Social participation is increasingly recognised as fundamental to stroke rehabilitation outcomes and quality of life. However, existing participation measures for stroke often face cultural and linguistic challenges when used with the ...
Surbala Lourembam, Dhruv Dave
doaj   +1 more source