Results 41 to 50 of about 274,445 (261)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Science of Gymnastics JournalFlexibility is a foundational motor skill in rhythmic gymnastics and is crucial for successful performance. While existing flexibility assessments, such as the frontal splits on an elevated surface, have been used in the field for years, psychometric ...
Ahsen Büyükaslan, Maja Pajek
doaj +1 more source
The Online Student Connectedness Survey: Evidence of Initial Construct Validity
International Review of Research in Open and Distributed Learning, 2017 The Online Student Connectedness Survey (OSCS) was introduced to the academic community in 2012 as an instrument designed to measure feelings of connectedness between students participating in online degree and certification programs. The purpose of this
Tekeisha Denise Zimmerman, Kim Nimon
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
REID (Research and Evaluation in Education)This study aims to reveal the content validity, construct validity, and reliability of the instrument for evaluating the teaching process in higher education. This research is development research applying the ADDIE model from Molenda.
Risky Setiawan +2 more
doaj +1 more source
Psychometric properties of the mentor behaviour scale in a sample of Malaysian medical students
Journal of Taibah University Medical Sciences, 2018 Objectives: To determine the psychometric properties of the Mentor Behaviour Scale (MBS), a 15-item inventory that evaluates four supportive mentor behaviours in terms of construct validity and internal consistency.
Jamilah A.M. Mohammad, MEd +1 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
IEEE AccessTelemedicine has the potential to enhance both the accessibility and quality of healthcare services. Patients can access telemedicine through various modes, including applications.
Ni Luh Saddhwi Saraswati Adnyani +3 more
doaj +1 more source