Results 91 to 100 of about 8,621,457 (276)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mathematical models of multi-barreled construction artillery systems

Structural Mechanics of Engineering Constructions and Buildings, 2018
The article presents the schematic diagrams and mathematical models of multi-barrel artillery systems designed for shooting and extraction of building elements from the ground, describes the results of numerical experiments carried out on the basis of ...
Oleg L Figovsky, Oleg G Pensky
doaj   +1 more source

Sector skills insights : construction [PDF]

, 2012
The UK Commission for Employment and Skills is a social partnership, led by Commissioners from large and small employers, trade unions and the voluntary sector.
Atfield, Gaby, Breuer, Zoey, Gambin, Lynn, Garrett, Richard, Hogarth, Terence, Li, Yuxin, Owen, David   +6 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Achieving sustainable construction in the developing countries Of Southeast Asia [PDF]

, 2006
Sustainable construction is a way for the building industry to move towards achieving sustainable development, taking into account environmental, socioeconomic and cultural issues.
Arman Ali, Zainab, Othman, Mohamed Zahry, Shafii, Faridah   +2 more
core  

Constructive correction

EMBO reports, 2023
A fundamental tenet of the scientific process is that science is self‐correcting. Efficient correction of the scientific literature requires a more nuanced set of policies and tools that lower the bar to author self‐correction. The community has to embrace correction as a signal of scholarly quality.
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Minor rotor tines and knives soil interaction. Total power calculation for minor rotor drive

Вестник СибАДИ
Introduction. The problem of fast and high-quality road construction, when economic facilities and settlements are spatially separated, located at a considerable distance from each other, cannot be solved without the use of a complex of continuous units.
V. A. Nikolaiev
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source