Results 121 to 130 of about 3,507,125 (317)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Construction Machines as a Source of Construction noise
Procedia Engineering, 2017 Abstract The contribution deals with issues concerning the modelling of the production area of a construction site from the aspect of the placement of construction machines, which are a source of noise for the protected area outside the site according to Government Regulation No. 272/2011 Coll. It covers the determination of a construction site noise
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2007 The Your Building Project to build a website as the business and technical guide to\ud sustainable commercial buildings has now been completed. The site is available at\ud www.yourbuilding.org.
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Pillbox of Kedunglangkap, Kencong, Jember, East Java: A Reminder of The Japanese Colonization Era
Yupa: Historical Studies JournalMany evidence supports that human built structures, sites, or other relic of past activities in places deemed essential to life based on human observations of the geopolitical conditions.
Mahrus Afandi, Ari Sapto, Joko Sayono
doaj +1 more source
, 2007 Off-site Manufacture (OSM) has long been recognised, both in Australia and internationally,\ud as offering numerous benefits to all parties in the construction process. More importantly, it is\ud recognised as a key vehicle for driving improvement within
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Canada's National Model Construction Codes Development System
, 2013 The National Model Construction Codes are devel-oped and maintained using a broad-based consen-sus process. Individuals from all segments of the Canadian construction community have the oppor-tunity to contribute to the development of the codes, either ...
National Research Council Canada. Construction
core +1 more source
Constructions and context: when a construction constructs context
, 2009 The aim of the paper is to address a case of a syntactic pattern involving context, which can be summed up by this assumption : a construction provides pieces of context that the speaker considers to be necessary for the addressee to get a relevant interpretation of the current utterance.
Deulofeu, Jose, Debaisieux, Jeanne-Marie
openaire +1 more source