Results 131 to 140 of about 3,507,125 (317)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

HUMAN RESISTANCE TO THE USE OF INFORMATION TECHNOLOGY IN CONSTRUCTION COMPANIES

open access: yesCivil Engineering Dimension, 2005
The process of implementing information technology (IT) often fails to bring the intended result because the human dimension is not given adequate consideration.
Andi Andi, Fani Fani, Heru Purwoadi
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Seeing Our Quantitative Counterparts: Construction of Qualitative Research in a Roundtable Discussion

open access: yesForum: Qualitative Social Research, 2001
The research relationship between qualitative and quantitative researchers is influenced by their constructions of one another's research approaches. While we, as qualitative researchers, have our own construction of quantitative research we seldom get ...
Jean A. Saludadez, Primo G. Garcia
doaj  

Brite innovation survey : executive summary

open access: yes, 2005
This report summarises the fi ndings of an innovation survey\ud of the Australian construction industry undertaken by the\ud BRITE Project of the CRC for Construction Innovation in\ud 2004.

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Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

FAKTOR-FAKTOR PENYEBAB REWORK PADA PEKERJAAN KONSTRUKSI

open access: yesCivil Engineering Dimension, 2005
Rework cannot be separated from construction projects. The direct and indirect cost resulting from it are quite significant. This research aims to identify the causes of rework and to propose effective ways to reduce it.
Andi Andi   +2 more
doaj  

Business Drivers for BIM

open access: yes, 2007
his report describes in detail a project aimed at providing a better understanding of the business drivers and barriers to the adoption of Building Information Modelling (BIM) in the Architecture Engineering and Construction (AEC) and facility management

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Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Other title: 2013 construction administration manual of procedures; Other title: Title from Office of Construction Administration home page: 2013 manual of procedures for construction inspection

open access: yes, 2013
Accompanied by: Construction inspection forms booklet.This manual provides construction personnel with information to effectively administer the project and to perform accurate inspections and documentation of the construction work ...
Ohio. Department of Transportation. Office of Construction Administration.
core  

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