Results 91 to 100 of about 2,425,065 (336)

A Vision of Collaborative Verification-Driven Engineering of Hybrid Systems [PDF]

, 2013
. Hybrid systems with both discrete and continuous dynamics are an important model for real-world physical systems. The key challenge is how to ensure their correct functioning w.r.t. safety requirements.
Mitsch, Stefan, Passmore, Grant Olney, Platzer, André   +2 more
core   +4 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Constructing living buildings: a review of relevant technologies for a novel application of biohybrid robotics [PDF]

, 2019
Biohybrid robotics takes an engineering approach to the expansion and exploitation of biological behaviours for application to automated tasks. Here, we identify the construction of living buildings and infrastructure as a high-potential application ...
Bar-Yam Y, Bonabeau E, Calkins M, Chaudhuri P, Ching FDK, Daas M, Daniel Nicolas Hofstadler, Danks SG, Ednie-Brown P, Elsayed S, Erlandson W, Gandy M, Gibaldi J, Gramazio F, Gunther N, Heiko Hamann, Hughes TJR, Joachim M, Johnson D, Jørgensen RN, Kalberer M, Kalberer M, Kasper Stoy, Katola K, Kirsch K, Ludwig F, Mary Katherine Heinrich, Mohammad Divband Soorati, Mostafa Wahby, Nagaraja H, Payam Zahadat, Phil Ayres, Proksch G, Pérez G, Rafał Krela, Rafiei MH, Reames R, Reames R, Russell S, Schaeffer J, Schmitz V, Schweitzer F, Sebastian von Mammen, Slavid R, Soorati MD, Thomas Schmickl, Thouand G, Tomasz Skrzypczak, Wahby M, Warnes J, Wojciech Kwiatkowski, Wooldridge M, Yu Y   +52 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mechanism of surface and interface engineering under diverse dimensional combinations: the construction of efficient nanostructured MXene-based photocatalysts

, 2021
Xiaojuan Bai, Shanshan Hou, Xuyu Wang, Derek Hao, Boxuan Sun, Tianqi Jia, Rui Shi, Bing‐Jie Ni   +7 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Construction and Application of a Virtual Simulation Experimental Teaching Center for Chemistry and Chemical Engineering [PDF]

, 2021
Bin Wang, Chuanli Qin, Yifu Liu, Shaoping Sun   +3 more
openalex   +1 more source

Bioengineering Techniques for Soil Erosion Protection and Slope Stabilization [PDF]

The use of bio-engineering methods for soil erosion protection and slope stabilization has a long tradition. Old methods with rocks and plants, structures of timber have been used over the past centuries.
Ioannis Stathakopoulos, Julia Georgi
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Application of BIM + vision technology in complex deep foundation pit [PDF]

E3S Web of Conferences
In recent years, the combination of building information model (BuildingInformationModeling, BIM) and vision technology has been widely used in the field of engineering construction, especially in the application of complex foundation pit engineering has
Wang Tao, Cao Wei, Shi Lei, Liu Zhixin, Tu Yi, Jiang Wei   +5 more
doaj   +1 more source