Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
SafetyThis study investigates the influence of adaptive leadership on crisis management effectiveness in complex construction engineering projects in Saudi Arabia.
Ahmed Faleh Alanazi +3 more
doaj +1 more source
Public policy implications of construction innovation research [PDF]
, 2006 This report undertakes an exploratory analysis of Construction Innovation research projects\ud in order to answer the question “What are the public policy implications of Construction\ud Innovation research?
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Construction procurement systems : a linkage with project organisational models [PDF]
, 1998 This paper constitutes a literature review undertaken at the start of a two and a half year EPSRC funded research project. As such, its purpose is to present the details of the ‘re-search’concerning construction procurement and project organizational ...
Langford, David, Murray, Michael
core +3 more sources
An Ontology-Driven MCP Agent Framework for Ensuring Integrity in Architectural Structural Design
IEEE AccessThe rapid proliferation of Large Language Model (LLM)-based autonomous agents has demonstrated strong potential for automating knowledge-intensive tasks.
Inkwan Paik +4 more
doaj +1 more source
Early intervention mechanism for preventing electrocution in construction engineering. [PDF]
Ind Health, 2021 Shiau YR, Lo FY, Ko PC.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Valorization of steel fiber from discarded tires in fly ash concrete
Revista Facultad de Ingeniería Universidad de AntioquiaThe construction sector continues to grow, but it is always looking for materials that do not generate CO2 during their production. Therefore, this research evaluates the physical and mechanical properties of concrete by using fly ash (FA) as a partial ...
Nicolás Reynaldo Robles-Godier +7 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source