Results 121 to 130 of about 2,451,925 (307)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Valorization of steel fiber from discarded tires in fly ash concrete
Revista Facultad de Ingeniería Universidad de AntioquiaThe construction sector continues to grow, but it is always looking for materials that do not generate CO2 during their production. Therefore, this research evaluates the physical and mechanical properties of concrete by using fly ash (FA) as a partial ...
Nicolás Reynaldo Robles-Godier +7 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
An Ontology-Driven MCP Agent Framework for Ensuring Integrity in Architectural Structural Design
IEEE AccessThe rapid proliferation of Large Language Model (LLM)-based autonomous agents has demonstrated strong potential for automating knowledge-intensive tasks.
Inkwan Paik +4 more
doaj +1 more source
Systems engineering studies of lunar base construction [PDF]
Many ingenious concepts have been proposed for lunar base construction, but few systematic studies exist which relate time-consistent lunar base construction technologies and the choice of lunar base approach with the long-term SEI objectives - i.e ...
Morgenthaler, George W.
core +1 more source
On ADE Quiver Models and F-Theory Compactification
, 2005 Based on mirror symmetry, we discuss geometric engineering of N=1 ADE quiver models from F-theory compactifications on elliptic K3 surfaces fibered over certain four-dimensional base spaces.
A Belhaj +14 more
core +1 more source
An Introduction to Civil Engineering Construction Technology in Civil Engineering Construction
Studies in Social Science ResearchThe commercial demand and urbanization demand brought about by economic development have increased the quantity and quality requirements of construction projects. Civil engineering in the construction process needs to be supported by a number of technologies, such as foundation technology, steel structure technology, concrete technology, etc., the only
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Cost engineering in construction [PDF]
Строительство уникальных зданий и сооружений, 2014 As the complexity of processes and increase the diversity of productions, development of technical means to control process changes related to formal assessment and methods.
Irina Stanislavovna Ptuhina +2 more
doaj